Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VapB |
| Location | 3018010..3018689 | Replicon | chromosome |
| Accession | NZ_CP063804 | ||
| Organism | Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P9WF90 |
| Locus tag | RJtmp_RS14370 | Protein ID | WP_003414059.1 |
| Coordinates | 3018010..3018426 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TF64 |
| Locus tag | RJtmp_RS14375 | Protein ID | WP_003414061.1 |
| Coordinates | 3018423..3018689 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RJtmp_RS14345 (RJtmp_002840) | 3014062..3014964 | - | 903 | WP_003414051.1 | 4-hydroxy-tetrahydrodipicolinate synthase | - |
| RJtmp_RS14350 (RJtmp_002841) | 3015033..3015785 | - | 753 | WP_003414053.1 | FAD-dependent thymidylate synthase | - |
| RJtmp_RS14360 (RJtmp_002842) | 3016029..3016304 | - | 276 | WP_003414055.1 | type I restriction endonuclease subunit S | - |
| RJtmp_RS14365 (RJtmp_002843) | 3016301..3017923 | - | 1623 | WP_003414057.1 | class I SAM-dependent DNA methyltransferase | - |
| RJtmp_RS14370 (RJtmp_002844) | 3018010..3018426 | - | 417 | WP_003414059.1 | type II toxin-antitoxin system toxin ribonuclease C21 | Toxin |
| RJtmp_RS14375 (RJtmp_002845) | 3018423..3018689 | - | 267 | WP_003414061.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| RJtmp_RS14380 (RJtmp_002846) | 3018715..3019110 | - | 396 | WP_003414064.1 | type II toxin-antitoxin system VapC family toxin | - |
| RJtmp_RS14385 (RJtmp_002847) | 3019107..3019376 | - | 270 | WP_003414066.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| RJtmp_RS14390 (RJtmp_002848) | 3019386..3020480 | - | 1095 | WP_003414068.1 | restriction endonuclease subunit S | - |
| RJtmp_RS14395 (RJtmp_002849) | 3020477..3020895 | - | 419 | Protein_2842 | winged helix-turn-helix domain-containing protein | - |
| RJtmp_RS14400 (RJtmp_04365) | 3020894..3020968 | + | 75 | Protein_2843 | hypothetical protein | - |
| RJtmp_RS14405 (RJtmp_002850) | 3020969..3021448 | - | 480 | WP_003414073.1 | dihydrofolate reductase | - |
| RJtmp_RS14410 (RJtmp_002851) | 3021519..3022319 | - | 801 | WP_003911953.1 | thymidylate synthase | - |
| RJtmp_RS14415 (RJtmp_002852) | 3022418..3023155 | + | 738 | WP_003414079.1 | dienelactone hydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15773.00 Da Isoelectric Point: 7.1294
>T178886 WP_003414059.1 NZ_CP063804:c3018426-3018010 [Mycobacterium orygis]
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
Download Length: 417 bp
>T178886 NZ_CP084398:1565197-1565724 [Sphingobium sp. CFD-1]
ATGACGCTTCCTTCATGGCACGAGGAAGCGATTTCGAAAGCGCATGACCGGACTTCATTCGACTGCGGCGACAATGATCT
GAACGTCTACTTGCAGCGTTATGCGCGGCAAAGCCACGAGGCAGGCGGGGCGAAGACGTTCCTCGCCATCGACGACACCG
ACAGCAAGACGGTTCTCGGCTTTTACAGCATCGCTCCGGGCAGCATGGATCATGCGGATACGCCAGAACTGGCGAGGCGA
GGACTCGCCAGGCATGAGGTGCCGGGCTTCCGGCTCGCGCGGCTAGCAACGGATCTGCGTGTGCAGGGGCAAGGGCTCGG
GGGTCAGCTCCTGGGCGCGATCGGGCGCAGATGCATTCGCGTCGCGACCGAGGTCGGCGGGGTTATGCTGATCATCGACG
CCAAAAACGAGCGCGCCGCGGACTGGTATGCCGGCTACGGCGCTATTCCGCTGCACGACAAACCGCTGACGCTCATATTG
CCCTTTGCGACACTCGAACGTGAATTGAGAGCTGCAGGCCAGTTCTAG
ATGACGCTTCCTTCATGGCACGAGGAAGCGATTTCGAAAGCGCATGACCGGACTTCATTCGACTGCGGCGACAATGATCT
GAACGTCTACTTGCAGCGTTATGCGCGGCAAAGCCACGAGGCAGGCGGGGCGAAGACGTTCCTCGCCATCGACGACACCG
ACAGCAAGACGGTTCTCGGCTTTTACAGCATCGCTCCGGGCAGCATGGATCATGCGGATACGCCAGAACTGGCGAGGCGA
GGACTCGCCAGGCATGAGGTGCCGGGCTTCCGGCTCGCGCGGCTAGCAACGGATCTGCGTGTGCAGGGGCAAGGGCTCGG
GGGTCAGCTCCTGGGCGCGATCGGGCGCAGATGCATTCGCGTCGCGACCGAGGTCGGCGGGGTTATGCTGATCATCGACG
CCAAAAACGAGCGCGCCGCGGACTGGTATGCCGGCTACGGCGCTATTCCGCTGCACGACAAACCGCTGACGCTCATATTG
CCCTTTGCGACACTCGAACGTGAATTGAGAGCTGCAGGCCAGTTCTAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 9493.77 Da Isoelectric Point: 7.2783
>AT178886 WP_003414061.1 NZ_CP063804:c3018689-3018423 [Mycobacterium orygis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
Download Length: 267 bp
>AT178886 NZ_CP084398:1564955-1565200 [Sphingobium sp. CFD-1]
ATGAGCCTGCGGATTCGGCCGGAGCAAAAGGCTTTGCTTGCCCGGGCGGCTGCGCTCAAGCATACCGATCTCACGACCTT
TGTCACACGTTCGGCGCTGCGCGAGGCCGAGAACGTGATCGAAGAGTCGGAGCGGACGAAACTGAGCGAGAGAGACAGCC
TGCTCGTTCTTGATCTGCTCGAGAACCCGCCGCCGGTGAATGCGAAACTGCGCGCTGCCATCGCCGCGATGCCGAAGTTG
GCATGA
ATGAGCCTGCGGATTCGGCCGGAGCAAAAGGCTTTGCTTGCCCGGGCGGCTGCGCTCAAGCATACCGATCTCACGACCTT
TGTCACACGTTCGGCGCTGCGCGAGGCCGAGAACGTGATCGAAGAGTCGGAGCGGACGAAACTGAGCGAGAGAGACAGCC
TGCTCGTTCTTGATCTGCTCGAGAACCCGCCGCCGGTGAATGCGAAACTGCGCGCTGCCATCGCCGCGATGCCGAAGTTG
GCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|