Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2888786..2889500 Replicon chromosome
Accession NZ_CP063804
Organism Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag RJtmp_RS13615 Protein ID WP_003413460.1
Coordinates 2889060..2889500 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag RJtmp_RS13610 Protein ID WP_003413456.1
Coordinates 2888786..2889073 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RJtmp_RS13575 (RJtmp_002686) 2884208..2884453 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
RJtmp_RS13580 (RJtmp_002687) 2884450..2884854 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
RJtmp_RS13585 (RJtmp_002688) 2885071..2885691 + 621 WP_003413441.1 DUF4178 domain-containing protein -
RJtmp_RS13590 (RJtmp_002689) 2885702..2886196 + 495 WP_003413444.1 DUF2617 family protein -
RJtmp_RS13595 (RJtmp_002690) 2886193..2886624 + 432 WP_003413445.1 DUF4247 domain-containing protein -
RJtmp_RS13600 (RJtmp_002691) 2886649..2887107 + 459 WP_003413451.1 DUF350 domain-containing protein -
RJtmp_RS13605 (RJtmp_002692) 2887104..2888675 + 1572 WP_003413453.1 polyamine aminopropyltransferase -
RJtmp_RS13610 (RJtmp_002693) 2888786..2889073 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
RJtmp_RS13615 (RJtmp_002694) 2889060..2889500 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
RJtmp_RS13620 (RJtmp_002695) 2889521..2890276 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
RJtmp_RS13625 (RJtmp_002696) 2890409..2891005 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
RJtmp_RS13630 (RJtmp_002697) 2891013..2891858 - 846 WP_003413466.1 acyl-CoA thioesterase II -
RJtmp_RS13635 (RJtmp_002698) 2891887..2892786 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
RJtmp_RS13640 (RJtmp_002699) 2892914..2893588 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T178885 WP_003413460.1 NZ_CP063804:2889060-2889500 [Mycobacterium orygis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T178885 NZ_CP084398:c945510-944995 [Sphingobium sp. CFD-1]
GTGGCGGACATCCGCATCACGCCACCCGCGCGTCTGACCGCCGATCACGATGTCGCGGGCTTCGCCAATGGCGTGCATGC
CTCGCTCGATGACTGGCTGCGGGACCGCGCGCTGGCGAGCGAGGGGAGTTCGGCGCGCACCTATGTCGTCTGCAATGCCG
CCGAGCCGCGCCGGGTGGTCGGCTACTATACGATCACGACCGCGATGGAGCAGCGGGCTGCTCTGCCGTCCGCGAAGCTG
CGGCGCGGCATGCCCGACCGGGTGCCGCTGCTCCTGATCGGCCGGCTCGCCGTTGATGCCGGGTTCCAGGGCATCGGCCT
TGGCGCCGATCTTCTGGCCGATGCGCTCCGGCGCTGCGCCGCGGCAGCCGAGATTGCCGGTGCGCGCGCGGTGATCGTTC
ATGCGATCGACGAAAAGGCGGCGGCGTTTTATGCGCGGCACGGGTTTATCCCTACCTCGCTCGGCGAACTGGTCATGCTG
CTGCCGATCGAGGCAATCCGCTCGCGGCCGAACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT178885 WP_003413456.1 NZ_CP063804:2888786-2889073 [Mycobacterium orygis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT178885 NZ_CP084398:c945834-945526 [Sphingobium sp. CFD-1]
ATGGCGCAGACGACACCTGCACATCCGAACGGGCGGGCTTCCGCCCGCAAGGACGATGTCATCCAGATCAGGGCGTCGGC
GGGTATGAAGGCCATTCTCACCCGTGCCGCCGCGCTGCGCGGTCAGAAGCTGTCCGAGTTCATGCTCGACAGCGCGCGGC
GCGAAGCGGAGGACGCCATTCTCGATCAGCGCACCTTCTTCCTCGACGCGGAGCAGCATGAGCAATTCCTCGCCATGCTC
GATGCCCCGCCCGCGCCGTCCGACGCTCTGCAGACCCTCATGCGGCGCAAGCCGATCTGGGAACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References