Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2378280..2378809 Replicon chromosome
Accession NZ_CP063804
Organism Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag RJtmp_RS11200 Protein ID WP_003411124.1
Coordinates 2378280..2378597 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag RJtmp_RS11205 Protein ID WP_003411127.1
Coordinates 2378594..2378809 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RJtmp_RS11170 (RJtmp_002206) 2373301..2374377 + 1077 WP_003411110.1 hypothetical protein -
RJtmp_RS11175 (RJtmp_002207) 2374374..2374655 + 282 WP_003411112.1 DUF5703 family protein -
RJtmp_RS11180 (RJtmp_002208) 2374691..2375764 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
RJtmp_RS11185 (RJtmp_002209) 2375769..2376299 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
RJtmp_RS11190 (RJtmp_002210) 2376347..2377693 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
RJtmp_RS11200 (RJtmp_002212) 2378280..2378597 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RJtmp_RS11205 (RJtmp_002213) 2378594..2378809 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
RJtmp_RS11210 (RJtmp_002214) 2379064..2380122 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
RJtmp_RS11215 (RJtmp_002215) 2380252..2380608 - 357 WP_003411130.1 hypothetical protein -
RJtmp_RS11220 (RJtmp_002216) 2380703..2381485 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
RJtmp_RS11225 (RJtmp_002217) 2381753..2382043 - 291 WP_003411132.1 YggT family protein -
RJtmp_RS11230 (RJtmp_002218) 2382205..2382861 - 657 WP_003411133.1 cell division protein SepF -
RJtmp_RS11235 (RJtmp_002219) 2382927..2383703 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T178879 WP_003411124.1 NZ_CP063804:c2378597-2378280 [Mycobacterium orygis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T178879 NZ_CP084397:c4731739-4731206 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT178879 WP_003411127.1 NZ_CP063804:c2378809-2378594 [Mycobacterium orygis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT178879 NZ_CP084397:c4732016-4731750 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References