Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2341473..2342168 Replicon chromosome
Accession NZ_CP063804
Organism Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag RJtmp_RS10995 Protein ID WP_003410811.1
Coordinates 2341473..2341907 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag RJtmp_RS11000 Protein ID WP_003410814.1
Coordinates 2341914..2342168 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RJtmp_RS10985 (RJtmp_002170) 2337627..2340668 + 3042 WP_003410791.1 DEAD/DEAH box helicase -
RJtmp_RS10990 (RJtmp_002171) 2340661..2341494 + 834 WP_003899172.1 SWIM zinc finger family protein -
RJtmp_RS10995 (RJtmp_002172) 2341473..2341907 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
RJtmp_RS11000 (RJtmp_002173) 2341914..2342168 - 255 WP_003410814.1 antitoxin Antitoxin
RJtmp_RS11005 (RJtmp_002174) 2342184..2342441 - 258 WP_003410816.1 hypothetical protein -
RJtmp_RS11010 (RJtmp_002175) 2343388..2343684 + 297 WP_003410820.1 PE family protein -
RJtmp_RS11015 (RJtmp_002176) 2343740..2344471 + 732 WP_140035306.1 PPE family protein -
RJtmp_RS11020 (RJtmp_002177) 2345011..2345757 - 747 WP_003411014.1 proteasome subunit alpha -
RJtmp_RS11025 (RJtmp_002178) 2345754..2346629 - 876 WP_003411023.1 proteasome subunit beta -
RJtmp_RS11030 (RJtmp_002179) 2346626..2346820 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T178878 WP_003410811.1 NZ_CP063804:c2341907-2341473 [Mycobacterium orygis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T178878 NZ_CP084397:4103773-4103991 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT178878 WP_003410814.1 NZ_CP063804:c2342168-2341914 [Mycobacterium orygis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT178878 NZ_CP084397:4103372-4103746 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References