Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2207138..2208036 Replicon chromosome
Accession NZ_CP063804
Organism Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag RJtmp_RS10400 Protein ID WP_003410001.1
Coordinates 2207138..2207698 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag RJtmp_RS10405 Protein ID WP_003410003.1
Coordinates 2207695..2208036 (-) Length 114 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RJtmp_RS10370 (RJtmp_002047) 2202307..2202960 - 654 WP_003409976.1 cutinase Cfp21 -
RJtmp_RS10375 (RJtmp_002048) 2203075..2203305 + 231 WP_003409980.1 DUF167 domain-containing protein -
RJtmp_RS10380 (RJtmp_002049) 2203390..2204301 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
RJtmp_RS10385 (RJtmp_002050) 2204410..2205009 + 600 WP_003409989.1 L-lysine exporter -
RJtmp_RS10390 (RJtmp_002051) 2205425..2205853 + 429 WP_003409992.1 cellulose-binding protein -
RJtmp_RS10395 (RJtmp_002052) 2206079..2206618 + 540 WP_003409994.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
RJtmp_RS10400 (RJtmp_002053) 2207138..2207698 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
RJtmp_RS10405 (RJtmp_002054) 2207695..2208036 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
RJtmp_RS10410 (RJtmp_002055) 2208122..2208379 + 258 WP_003410006.1 hypothetical protein -
RJtmp_RS10415 (RJtmp_002056) 2208280..2208615 - 336 WP_003410009.1 dehydrogenase -
RJtmp_RS10420 (RJtmp_002057) 2208704..2209048 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
RJtmp_RS10425 (RJtmp_002058) 2209042..2209290 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
RJtmp_RS10430 (RJtmp_002059) 2209390..2211705 - 2316 WP_003410016.1 cation transporter ATPase CptG -
RJtmp_RS10435 (RJtmp_002060) 2211702..2211974 - 273 WP_003410017.1 DUF1490 family protein -
RJtmp_RS10440 (RJtmp_002061) 2212027..2212383 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(25-148)

Antitoxin

(69-110)


Sequences


Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T178873 WP_003410001.1 NZ_CP063804:c2207698-2207138 [Mycobacterium orygis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T178873 NZ_CP084397:834546-834956 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT178873 WP_003410003.1 NZ_CP063804:c2208036-2207695 [Mycobacterium orygis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT178873 NZ_CP084397:834299-834565 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6FKG


Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References