Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2199812..2200500 Replicon chromosome
Accession NZ_CP063804
Organism Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag RJtmp_RS10355 Protein ID WP_003409958.1
Coordinates 2199812..2200231 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag RJtmp_RS10360 Protein ID WP_003409968.1
Coordinates 2200240..2200500 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RJtmp_RS10325 (RJtmp_002039) 2194817..2195122 + 306 Protein_2041 ABC transporter permease -
RJtmp_RS10330 (RJtmp_04300) 2195118..2195198 + 81 Protein_2042 hypothetical protein -
RJtmp_RS10335 (RJtmp_002040) 2195306..2196154 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
RJtmp_RS10340 (RJtmp_002041) 2196117..2197562 - 1446 WP_003409946.1 APC family permease -
RJtmp_RS10345 (RJtmp_002042) 2197741..2198427 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
RJtmp_RS10350 (RJtmp_002043) 2198618..2199586 - 969 WP_003409956.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
RJtmp_RS10355 (RJtmp_002044) 2199812..2200231 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
RJtmp_RS10360 (RJtmp_002045) 2200240..2200500 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
RJtmp_RS10365 (RJtmp_002046) 2200643..2202319 + 1677 WP_003409971.1 PecA family PE domain-processing aspartic protease -
RJtmp_RS10370 (RJtmp_002047) 2202307..2202960 - 654 WP_003409976.1 cutinase Cfp21 -
RJtmp_RS10375 (RJtmp_002048) 2203075..2203305 + 231 WP_003409980.1 DUF167 domain-containing protein -
RJtmp_RS10380 (RJtmp_002049) 2203390..2204301 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
RJtmp_RS10385 (RJtmp_002050) 2204410..2205009 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T178872 WP_003409958.1 NZ_CP063804:c2200231-2199812 [Mycobacterium orygis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T178872 NZ_CP084397:357108-357455 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTGGGATGTGGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATAAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT178872 WP_003409968.1 NZ_CP063804:c2200500-2200240 [Mycobacterium orygis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT178872 NZ_CP084397:357455-357754 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAAAGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References