Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2190812..2191356 | Replicon | chromosome |
| Accession | NZ_CP063804 | ||
| Organism | Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | RJtmp_RS10295 | Protein ID | WP_003409896.1 |
| Coordinates | 2190812..2191108 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | RJtmp_RS10300 | Protein ID | WP_003409899.1 |
| Coordinates | 2191105..2191356 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RJtmp_RS10240 (RJtmp_002022) | 2185845..2186195 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| RJtmp_RS10245 (RJtmp_002023) | 2186206..2187108 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| RJtmp_RS10250 (RJtmp_002024) | 2187129..2187320 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| RJtmp_RS10255 (RJtmp_002025) | 2187321..2187617 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| RJtmp_RS10260 (RJtmp_002026) | 2187857..2188072 | + | 216 | WP_003409878.1 | antitoxin | - |
| RJtmp_RS10265 (RJtmp_002027) | 2188069..2188380 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| RJtmp_RS10270 (RJtmp_002028) | 2188354..2188875 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| RJtmp_RS10275 (RJtmp_002029) | 2188850..2189227 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| RJtmp_RS10280 (RJtmp_002030) | 2189269..2189718 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| RJtmp_RS10285 (RJtmp_002031) | 2189715..2190260 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| RJtmp_RS10290 (RJtmp_002032) | 2190149..2190763 | - | 615 | WP_249739965.1 | hypothetical protein | - |
| RJtmp_RS10295 (RJtmp_002033) | 2190812..2191108 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| RJtmp_RS10300 (RJtmp_002034) | 2191105..2191356 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| RJtmp_RS10305 (RJtmp_002035) | 2191343..2191822 | + | 480 | WP_003409901.1 | hypothetical protein | - |
| RJtmp_RS10310 (RJtmp_002036) | 2191982..2192389 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| RJtmp_RS10315 (RJtmp_002037) | 2192393..2192665 | - | 273 | WP_003409916.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| RJtmp_RS10320 (RJtmp_002038) | 2192698..2193918 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| RJtmp_RS10325 (RJtmp_002039) | 2194817..2195122 | + | 306 | Protein_2041 | ABC transporter permease | - |
| RJtmp_RS10330 (RJtmp_04300) | 2195118..2195198 | + | 81 | Protein_2042 | hypothetical protein | - |
| RJtmp_RS10335 (RJtmp_002040) | 2195306..2196154 | + | 849 | WP_003409942.1 | class I SAM-dependent methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T178871 WP_003409896.1 NZ_CP063804:c2191108-2190812 [Mycobacterium orygis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T178871 NZ_CP084397:331139-331507 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGACAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGACAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT178871 WP_003409899.1 NZ_CP063804:c2191356-2191105 [Mycobacterium orygis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT178871 NZ_CP084397:330921-331142 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |