178867

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1951749..1952362 Replicon chromosome
Accession NZ_CP063804
Organism Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag RJtmp_RS09130 Protein ID WP_003408465.1
Coordinates 1951749..1952138 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag RJtmp_RS09135 Protein ID WP_003408469.1
Coordinates 1952135..1952362 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RJtmp_RS09095 (RJtmp_001794) 1947378..1948292 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
RJtmp_RS09100 (RJtmp_001795) 1948295..1949125 + 831 WP_003408448.1 cyclase family protein -
RJtmp_RS09105 (RJtmp_001796) 1949125..1949475 + 351 WP_003408450.1 cupin domain-containing protein -
RJtmp_RS09110 (RJtmp_001797) 1949528..1950346 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
RJtmp_RS09115 (RJtmp_001798) 1950360..1951139 + 780 WP_003408460.1 IclR family transcriptional regulator -
RJtmp_RS09125 (RJtmp_04270) 1951570..1951701 + 132 Protein_1800 IS3 family transposase -
RJtmp_RS09130 (RJtmp_001800) 1951749..1952138 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
RJtmp_RS09135 (RJtmp_001801) 1952135..1952362 - 228 WP_003408469.1 antitoxin Antitoxin
RJtmp_RS09140 (RJtmp_001802) 1952580..1954064 + 1485 WP_003408473.1 biotin carboxylase -
RJtmp_RS09145 (RJtmp_001803) 1954061..1955308 + 1248 WP_003408476.1 serine hydrolase -
RJtmp_RS09150 (RJtmp_001804) 1955351..1955770 - 420 WP_003408483.1 hypothetical protein -
RJtmp_RS09155 (RJtmp_001805) 1955760..1956470 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T178867 WP_003408465.1 NZ_CP063804:c1952138-1951749 [Mycobacterium orygis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T178867 NZ_CP084392:1674449-1674631 [Pseudochrobactrum sp. XF203]
ATGCTACGAGACAGTAAGAAGATTGTTAAACGCCTTGAAAATGAAGGGTTCGAATTAGTATCGGTGAAAGGCTCTCACCA
CAAATTCAGAAAAGGGGACATGACCATCATAGTTCCTCACCCCAAGAAAGACCTTCCGATCGGAACGGCCAAGGCAATAG
CGAAACAAGCGGGCTGGGAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT178867 WP_003408469.1 NZ_CP063804:c1952362-1952135 [Mycobacterium orygis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT178867 NZ_CP084392:1674693-1675091 [Pseudochrobactrum sp. XF203]
ATGAAACACTTCTTTGCATTGGTGCATAAAGATTCCGATAGTGCTTATGGTATTCAGTTTCCTGATCTACCAAGCGTCTT
TTCTGCGTCCGATGAGGCCGAAGATATCGTAAAGAACGCGATTGAAGCATTACAGCTTTATGCAGAAGACGAAACCTTAC
CTGAAGCTTCCAGTCATGCTGACATCGTAGCGCGTGATGATGTGCGCTCTGCATTGAATGACGGCGCATATCTCATCTCT
GTGCCATACATCGAAGACGACAGCGCCGTTGTCCGCGTGAATGTCACTTTTGAACGTGGAGTTCTTAAAGCAATCGACAA
TGTAGCCAAAGACCGCGGCTTAACCCGCTCGTCATTTCTGGCTCAAGCCGCACGTCATGAAATTGAGGTAGGCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAN9

References