Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1548417..1549467 Replicon chromosome
Accession NZ_CP063804
Organism Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag RJtmp_RS07360 Protein ID WP_003407164.1
Coordinates 1548417..1549238 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag RJtmp_RS07365 Protein ID WP_003407167.1
Coordinates 1549231..1549467 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RJtmp_RS07340 (RJtmp_001442) 1543975..1544637 - 663 WP_003407152.1 membrane protein -
RJtmp_RS07345 (RJtmp_001443) 1544634..1545419 - 786 WP_003407157.1 membrane protein -
RJtmp_RS07350 (RJtmp_001444) 1545710..1547671 - 1962 WP_003407159.1 sigma-F factor regulator -
RJtmp_RS07355 (RJtmp_001445) 1547810..1548196 - 387 WP_003407162.1 anti-sigma-F factor antagonist RsfA -
RJtmp_RS07360 (RJtmp_001446) 1548417..1549238 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
RJtmp_RS07365 (RJtmp_001447) 1549231..1549467 + 237 WP_003407167.1 hypothetical protein Antitoxin
RJtmp_RS07370 (RJtmp_001448) 1549539..1550618 - 1080 Protein_1451 serine hydrolase domain-containing protein -
RJtmp_RS07380 (RJtmp_001450) 1552405..1553190 + 786 WP_003407180.1 lipoprotein LprF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T178863 WP_003407164.1 NZ_CP063804:1548417-1549238 [Mycobacterium orygis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

>T178863 NZ_CP084384:1741144-1741476 [Lactobacillus helsingborgensis]
ATGGTAATTAAGCAAGGATCTATTCTATTAATGGATTTAAGTCCTAAACAGGGGCATGAACAATCTGGCAAACAACCTTA
TTTATATTTAAGCTATAACGGGGTTGAAAAATACGCTCATATTGCTGTGTTTGCTCCTATATCAACTACTAAAAGACGCT
ACCCCTTATATCAAGAATTACCTGCTGTATCTCAAACAAAAGGCGTAGTCATGCTAGATCAGCTAGTTACAATCGATTAT
CATAACCAACCATTTCATTATTTAGAGCAACTACCTGATGATTATATGGAAAAGATACTCAAAATTGTAAAAGTAGTTTT
TCAGAAAGATTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT178863 WP_003407167.1 NZ_CP063804:1549231-1549467 [Mycobacterium orygis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp

>AT178863 NZ_CP084384:1740899-1741150 [Lactobacillus helsingborgensis]
ATGATTCGTGCTACTATATCTAAATGGGGTAATTCTAAAGGCATCCGATTAAACCAAGCAGTCTTGCAAGCATTAAACGC
TACTATAGGAGATCAGTTAAACTTTAAAATTGAGGACAACAAAGTAATAATGTCAAAGCAAGATGATTCACCTGATTTAA
CTTTTGAAGAACTTTTTAAAGATTATTCAGGTGAAGAATTTGATACCGAAATTAAGTTACCAGATGAGAGAAAAGGAAAT
GAAAGATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References