Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1395926..1396461 Replicon chromosome
Accession NZ_CP063804
Organism Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145

Toxin (Protein)


Gene name relE Uniprot ID A0A829CCD6
Locus tag RJtmp_RS06685 Protein ID WP_003406309.1
Coordinates 1395926..1396195 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag RJtmp_RS06690 Protein ID WP_003406322.1
Coordinates 1396192..1396461 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RJtmp_RS06660 (RJtmp_001307) 1391503..1391763 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -
RJtmp_RS06665 (RJtmp_001308) 1391760..1392191 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
RJtmp_RS06670 (RJtmp_001309) 1392214..1393894 - 1681 Protein_1317 PE family protein -
RJtmp_RS06675 (RJtmp_001310) 1394074..1394934 + 861 WP_003406306.1 glycine betaine ABC transporter substrate-binding protein -
RJtmp_RS06680 (RJtmp_001311) 1395015..1395845 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
RJtmp_RS06685 (RJtmp_001312) 1395926..1396195 - 270 WP_003406309.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
RJtmp_RS06690 (RJtmp_001313) 1396192..1396461 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RJtmp_RS06695 (RJtmp_001314) 1396574..1400269 - 3696 WP_003406323.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
RJtmp_RS06700 (RJtmp_001315) 1400411..1401199 - 789 WP_003406325.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10020.34 Da        Isoelectric Point: 8.1338

>T178862 WP_003406309.1 NZ_CP063804:c1396195-1395926 [Mycobacterium orygis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASY

Download         Length: 270 bp

>T178862 NZ_CP084378:c40327-39395 [Lactococcus garvieae]
ATGAAAATGACACGGCTAAGGGATTTAATAGCTAGCCAACCTGGAATAACATCTGCAGATAATTATCAGATTAGATATGC
TATAGATAGATTTTTAGCTAGACTCGTGAAAAGTAAATATAAAGAGAACTTTGTCATAAAAGGAGGGTTTCTTCAAGGTG
TAATATATAATCTTGATCAAAGGGCTACAAGGGATTTAGATGCTTCAGTACGTGATATGAAAGCTAATTATACTGCTATT
GAGAAGGCAGTATTAGAAATTTGTAGTATACATTTGAATGATAATGTTTCTTTTAAGCTGCGGAGTTTAGAAAGTAGTCA
AGAAGGAAGAATCTATTCTGGTTTTAGAGCCAAATTGACCATGTCCTTTTTAGAAGAACGTACTAAAATAAACTTTGATC
TTGATATTGGCGTGGGAGATGAAATTACTCCTAGAGCTCAAAAAATAGAATTTCCTCTCTTATTTAGTGAAGAAAAAGGG
AAAACAGAAACTATCGAAATATTTGGCTACCCAAGACAAACAAGCCAGGCAGAAAAATTAGAAACTATTCTAGTGCGAGG
GTTATCAAATAGTCGTATGAAAGATTTTTATGATATGCATCTATTTTATAATGATCTAGAAAGCATTAGTGTGCACCAAT
CTTGTGAGGCATTTGTCAAAACATGGGAATTTAGACATCCAGAAACTGAAATTAATGAAGAATTATTCTTGGATTGGTTC
GATTTATTAGAAGATATTTCAAGCAATAAAAAATTTTTGAATGATTACTGGCCAAATTATACAAAAGATAAACCGTTTGC
TAGTCCATTAAGTTTTAAGGACATTGTTCAAGAGATAATTGAACTTTTAAAGAGCATTCAAGAAGAATATCTGACGAATA
AGGGAGAAAAATATGCTAGAGATAAGTCTTCTGACACAAAAGAGAAGCTTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT178862 WP_003406322.1 NZ_CP063804:c1396461-1396192 [Mycobacterium orygis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp

>AT178862 NZ_CP084378:c41179-40343 [Lactococcus garvieae]
ATGGATATATATAAGATTTCAAATATAAATTTAGATGAACAAAATAAAAAGAATTTAAAAAGAGTTGCAGAAAACATGCT
TTCGACTTTTGATGAAGAACAGCTTCAATCAATAATTAAAGTAATGATGACACCGTTCTATCAGAATGAACTTTCCTCGT
ATTTAATAGAAAAAACTCTTCCAGCGATTGGATCAGAAGAGTTTAATTTTCTACTACTAGCAAATAAATATAATGGTCAT
ATTATTCGAAAAATAGTTAAAGAAGAAGGGATAAGTGACTATTATTTAAGGAAATTCGTTGAAAAATATAGCCTTAAGGA
ACTAATTAAAGGAAGTTACATATTCCCAAATAAACCTGTAGATTATCTTTTTGTTTTGCAACAAAGATACAAGATTACGG
CTGTATCACATGAAACAGCTTTGTATATGCAGGAGTTAATAGACTACATTCCACAAGTAATTACAATAAGTATTCCAGAA
AAGTATAACGCTGACTTAATATACAATAGTTTTGTTCAAAATAGTTTTCTAAATAATGAACTTAATTTTCTAAAGAAGCT
AGGAGATAATCGAATAACTTTTGTTAAAAATAAACCAATCCCCCCATCTCAGATTATTGAATTGGCAGATGAAAATGGCT
TACCTTTGAGAGTGACCTCTGCCGAAAGGTCTGTGGTGGATATATTAAAATCCTCATATAAAGCGGACGAAGAGGTTAAA
GAACAAGCAGTAAACTCTTTTATACGTAGATTCCCAGAAAGAATTGCTCGTTTGAGACGTATAGCAAAAAATCAAAATAG
CCTTAAAGAGTTAGAAAATTATTTATTAAGATACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCD6

Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References