Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 1235324..1235955 | Replicon | chromosome |
Accession | NZ_CP063804 | ||
Organism | Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | A0A7U4F9D0 |
Locus tag | RJtmp_RS05920 | Protein ID | WP_003405820.1 |
Coordinates | 1235324..1235635 (-) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | G0TGZ7 |
Locus tag | RJtmp_RS05925 | Protein ID | WP_003405836.1 |
Coordinates | 1235635..1235955 (-) | Length | 107 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
RJtmp_RS05900 (RJtmp_001160) | 1230806..1232230 | - | 1425 | WP_003405805.1 | class II fumarate hydratase | - |
RJtmp_RS05905 (RJtmp_001161) | 1232261..1233349 | - | 1089 | WP_003898726.1 | class II fructose-bisphosphatase | - |
RJtmp_RS05910 (RJtmp_001162) | 1233405..1234049 | + | 645 | WP_003915494.1 | DUF4245 domain-containing protein | - |
RJtmp_RS05915 (RJtmp_001163) | 1234056..1235212 | - | 1157 | Protein_1165 | AI-2E family transporter | - |
RJtmp_RS05920 (RJtmp_001164) | 1235324..1235635 | - | 312 | WP_003405820.1 | type II toxin-antitoxin system toxin endoribonuclease MazF3 | Toxin |
RJtmp_RS05925 (RJtmp_001165) | 1235635..1235955 | - | 321 | WP_003405836.1 | type II toxin-antitoxin system antitoxin MazE3 | Antitoxin |
RJtmp_RS05930 (RJtmp_001166) | 1235965..1237501 | + | 1537 | Protein_1168 | carboxylesterase/lipase family protein | - |
RJtmp_RS05935 (RJtmp_001167) | 1237508..1238620 | - | 1113 | WP_003405840.1 | 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase | - |
RJtmp_RS05940 (RJtmp_001168) | 1238630..1238887 | - | 258 | WP_003405844.1 | exodeoxyribonuclease VII small subunit | - |
RJtmp_RS05945 (RJtmp_001169) | 1238877..1240124 | - | 1248 | WP_003405846.1 | exodeoxyribonuclease VII large subunit | - |
RJtmp_RS05950 (RJtmp_001170) | 1240121..1240759 | - | 639 | WP_003405849.1 | lipid droplet-associated protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 11061.82 Da Isoelectric Point: 4.9371
>T178859 WP_003405820.1 NZ_CP063804:c1235635-1235324 [Mycobacterium orygis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA
Download Length: 312 bp
>T178859 NZ_CP084357:c913338-913078 [Streptomyces sp. WA6-1-16]
GTGAAGTTCGTGTGGGACCAGTCGTCGTGGGACGACTACGTCTGGTGGCAGCACCAGGATCGCAAGATCCTCAAGAGGAT
CAACACGCTGCTCCAGGACATCGCCCGGAACGGCAACGAAGGAATGGGCAAGCCGGAGCCTCTGAAGCACGGCTTCCAGG
GGTACTGGTCCCGCCGTATCACCGACGAACACCGGCTCATCCACAAAGTGGTCGGCGACGAGGTCCGCATTGCCGCCTGC
CGCTACCACTACGGCCACTGA
GTGAAGTTCGTGTGGGACCAGTCGTCGTGGGACGACTACGTCTGGTGGCAGCACCAGGATCGCAAGATCCTCAAGAGGAT
CAACACGCTGCTCCAGGACATCGCCCGGAACGGCAACGAAGGAATGGGCAAGCCGGAGCCTCTGAAGCACGGCTTCCAGG
GGTACTGGTCCCGCCGTATCACCGACGAACACCGGCTCATCCACAAAGTGGTCGGCGACGAGGTCCGCATTGCCGCCTGC
CGCTACCACTACGGCCACTGA
Antitoxin
Download Length: 107 a.a. Molecular weight: 11394.83 Da Isoelectric Point: 5.1236
>AT178859 WP_003405836.1 NZ_CP063804:c1235955-1235635 [Mycobacterium orygis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID
Download Length: 321 bp
>AT178859 NZ_CP084357:c913586-913335 [Streptomyces sp. WA6-1-16]
ATGCGCACGATGACCTACACGGAGTCCCGCGCGAATTACGCCGAGACCCTGAGCGCGGTCGTGGACGACCGTGAAGAGGT
CGTGGTCACGCGGGCCGGCCACGAGCCCGTGGTGATAGTGGCGCTCGACGAGTACGAGTCCCTCAAGGAGACGGCGTACC
AGCTCCGGAGTCCGGAGAACGCCCGTCGACTGCTGGCTTCGATCGACCGCCTGGAGAGCGGCGGCGGCACGGTGCAGGAG
CTTGCGGAGTGA
ATGCGCACGATGACCTACACGGAGTCCCGCGCGAATTACGCCGAGACCCTGAGCGCGGTCGTGGACGACCGTGAAGAGGT
CGTGGTCACGCGGGCCGGCCACGAGCCCGTGGTGATAGTGGCGCTCGACGAGTACGAGTCCCTCAAGGAGACGGCGTACC
AGCTCCGGAGTCCGGAGAACGCCCGTCGACTGCTGGCTTCGATCGACCGCCTGGAGAGCGGCGGCGGCACGGTGCAGGAG
CTTGCGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4F9D0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TGZ7 |