Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1018342..1018961 Replicon chromosome
Accession NZ_CP063804
Organism Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag RJtmp_RS04845 Protein ID WP_003404726.1
Coordinates 1018527..1018961 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID G0TFQ5
Locus tag RJtmp_RS04840 Protein ID WP_003404724.1
Coordinates 1018342..1018521 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RJtmp_RS04825 (RJtmp_000956) 1013815..1015395 + 1581 WP_003909313.1 serine hydrolase -
RJtmp_RS04830 (RJtmp_000957) 1015392..1017785 + 2394 WP_003404718.1 cation-translocating P-type ATPase -
RJtmp_RS04835 (RJtmp_000958) 1018058..1018216 + 159 WP_003404720.1 hypothetical protein -
RJtmp_RS04840 (RJtmp_000959) 1018342..1018521 + 180 WP_003404724.1 antitoxin Antitoxin
RJtmp_RS04845 (RJtmp_000960) 1018527..1018961 + 435 WP_003404726.1 SRPBCC family protein Toxin
RJtmp_RS04850 (RJtmp_000961) 1019059..1019832 + 774 WP_003404735.1 VOC family protein -
RJtmp_RS04855 (RJtmp_000962) 1019897..1020346 + 450 WP_003404738.1 hypothetical protein -
RJtmp_RS04860 (RJtmp_000963) 1020481..1020711 - 231 WP_003404739.1 hypothetical protein -
RJtmp_RS04865 (RJtmp_000964) 1020878..1022386 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
RJtmp_RS04870 (RJtmp_000965) 1022388..1023626 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T178857 WP_003404726.1 NZ_CP063804:1018527-1018961 [Mycobacterium orygis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

>T178857 NZ_CP084349:3361721-3363037 [Aeromonas dhakensis]
ATGATGAATGGTTCTGAGCACCATCGGCTGGAACTTCGGCTGGGTAATCAGCTGATCGGCCATCTCGAATATGACTCCAA
CCGGGATTCGTTTCAGCTCGGCTATCTGCCAGAGTGGCAAGCGCGCGGATTCCCACTCTCACCGCCACTGGCGTTGGATG
GCTCGGCCAGCAGCGCTCAGATCCGGGCGTATCTCGGCAACTTACTGCCAGAAAATCGCGGGCTGGATCATCTGATTGAG
GTACTCTCCGTTTCGCGCAGCAATCTCTTTGCCCTGATCCACGGTATCGGCCGCGATGTATCCGGGGCTGTCACCTTCAC
CCTACCCGCAGAGCCCGACATTCCCACCCGGTTTCGCCCCATCACACCAGAGGAGTTGATGCTGCGCCTCGATCAACCCG
AGATTTGGCCACTGGAAGTCTGGGATGGCCGCTCCCGACTCTCGGTTGCGGGTGTGCAGGCCAAACTCAACCTGCTGCGA
CTCGAGGGGAGGCTAGGATTTGGCGAAGGTGAACTCTGTTCAACCCACCTCCTCAAGTTCGAGCATCACCCTCATCTGGT
GATCAATGAATTTGTAACCATGCAGCTGGCCGCACAGCTTAGCATGCCGGTGGCGCGGGTCGAACTGCATACTGTGGGTC
AGGGTGAGAAGTCCCACAGAAGCTTGCTGGTGGAACGGTTCGACCGTCGTCTTGATGAGGATGGCATGAGGGTCCGCCGT
CGCCACATGATCGATGCCTGTCAGGGGCTGGGGTTCCCCGTCGCCCGAAAATATGAACGCAACTTCGGTGATGGTCGGGA
CGTGGCCCATATTCGGGAAGGGGTGAGCCTGCCACGGCTGTTCAGCCTTAGCGCTCTCTGCGTCAATCCAGCGCAGGCCA
GACTGGACATGCTGCAATGGCTGCTCTTCAACCTCTGCGTCAACAATTACGATGCCCACGGCAAGAACTACAGCTTCTTC
GTATCAAAAGCAGGGCTGACGCCCACCCCTTGGTACGATCTGGTCAATGTGGGGCTTTACCCCGAGTTCAGCCAGCATCT
GGCCATGGCCATAGGCGACGAATTTGCTCCCGAGGCGATCAACGCATGGCAGTTGCTGGAAATGGCCGAGGCATGTGACC
TGCCCGAACGCCTGCTGCAACAGACCTTGCAGAAGATAGCCAGCGACATCCTCCACCATTTGGATGCCGCTATAGCCATG
GTCGAGACAGACCATCCCGCCGAGCTGGATTATCTGGCACGCTATAAAGATGACGTTGAGCGCCGTTGCCACCATTTTCA
GGAGCAGGCGGGGCTGTTGCCCGAACTGCAGCTATAG

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6394.06 Da        Isoelectric Point: 4.3059

>AT178857 WP_003404724.1 NZ_CP063804:1018342-1018521 [Mycobacterium orygis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLQDAASNVVGMSDQQS

Download         Length: 180 bp

>AT178857 NZ_CP084349:3361444-3361737 [Aeromonas dhakensis]
ATGACAGATACACCGTTGCCAACCGGCACGAAAGAACTGGATCCCGCCTCGCTGGGACTGGCGATACGGGAGAGACGCAA
AGCAGCCAAGATGACCCAAGAGGTGACGGCCTCACTGTGCGGCATCTCCAAGAAAACCCTGATCAAGATTGAAAAAGGGG
GGGATGTCTACCTCTCGACCCTGCTGCAGGTGATGAAGGCGCTGGGACTGAGGTTGCAACTGGTGCAAGAAGCGGGATCA
CAGGTAATGAGCAGCTACAGCCAACCAGAGGTCGGTGATGATGAATGGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G0TFQ5

References