Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 844565..845274 Replicon chromosome
Accession NZ_CP063804
Organism Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145

Toxin (Protein)


Gene name vapC Uniprot ID P9WF74
Locus tag RJtmp_RS03995 Protein ID WP_003403837.1
Coordinates 844846..845274 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag RJtmp_RS03990 Protein ID WP_003403834.1
Coordinates 844565..844822 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RJtmp_RS03980 (RJtmp_000789) 839808..842279 + 2472 Protein_787 PE family protein -
RJtmp_RS03985 (RJtmp_000790) 842678..844474 + 1797 WP_003403831.1 PE family protein -
RJtmp_RS03990 (RJtmp_000791) 844565..844822 + 258 WP_003403834.1 ribbon-helix-helix protein, CopG family Antitoxin
RJtmp_RS03995 (RJtmp_000792) 844846..845274 + 429 WP_003403837.1 type II toxin-antitoxin system VapC family toxin Toxin
RJtmp_RS04000 (RJtmp_000793) 845355..845492 - 138 WP_003403839.1 hypothetical protein -
RJtmp_RS04010 (RJtmp_000794) 845651..845896 + 246 WP_003403841.1 hypothetical protein -
RJtmp_RS04015 (RJtmp_000795) 845965..846849 - 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
RJtmp_RS04020 (RJtmp_000796) 846860..848032 - 1173 WP_003403845.1 acyl-CoA dehydrogenase family protein -
RJtmp_RS04025 (RJtmp_000797) 848039..849571 - 1533 WP_003403847.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15831.27 Da        Isoelectric Point: 7.5536

>T178856 WP_003403837.1 NZ_CP063804:844846-845274 [Mycobacterium orygis]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

>T178856 NZ_CP084345:69394-69693 [Yersinia pestis]
GTGTATAAACTGTCTGAACTAGCTGATGAGGATATTTATAATATTGCCAGTTATACTATCCGGCATTTCGGTGTGACTCA
GGCTAAGTTATACCATGAGAACTTGGCAAAGGTATTCGAGCTATTAGCTAAAAATCCAGAGTTAGGGGCTGAGTGTAACT
GGATTTGCTCTGATATTCGCCGTTTTCAGTATAAAAAGCACGGTATATACTATATAACGCTTAGCAATGATATTTTGATT
TCTCGAGTGCTGCATCAATCCATAGATATAGATGTTCAGGATTTTCCAGAGCATGAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT178856 WP_003403834.1 NZ_CP063804:844565-844822 [Mycobacterium orygis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp

>AT178856 NZ_CP084345:69159-69401 [Yersinia pestis]
ATGGCTCACGTAACCAGCGTAACACTTGGAGAGCATTTGACAGGTTTTGTGGGGGAAATGATTCAGTCTGGTCGTTATGG
CAATATATCAGAAGTGCTTCGTGATGCCTTAAGGCTAATGGAAGCACGTGAACAGCGTGTTCAACATGTACGCGATATGG
TGCTTGCAGGAACAAATGTACCTGTGAGCCATCGTTTAATGGATGAGATTTTTTCTGCTGCGGTGAAAGATACTAGTGTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDR3

Antitoxin

Source ID Structure
AlphaFold DB G0TEX4

References