Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 758024..758712 Replicon chromosome
Accession NZ_CP063804
Organism Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag RJtmp_RS03510 Protein ID WP_003403386.1
Coordinates 758024..758461 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O06777
Locus tag RJtmp_RS03515 Protein ID WP_003911263.1
Coordinates 758458..758712 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RJtmp_RS03480 (RJtmp_000691) 754275..755285 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
RJtmp_RS03485 (RJtmp_000692) 755673..756056 - 384 WP_003403365.1 ribonuclease VapC6 -
RJtmp_RS03490 (RJtmp_000693) 756151..756306 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
RJtmp_RS03495 (RJtmp_000694) 756382..757098 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
RJtmp_RS03500 (RJtmp_000695) 757374..757682 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
RJtmp_RS03505 (RJtmp_000696) 757669..757914 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
RJtmp_RS03510 (RJtmp_000697) 758024..758461 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
RJtmp_RS03515 (RJtmp_000698) 758458..758712 - 255 WP_003911263.1 antitoxin VapB7 Antitoxin
RJtmp_RS03520 (RJtmp_000699) 758826..761189 + 2364 WP_003403397.1 arylsulfatase AtsD -
RJtmp_RS03525 (RJtmp_000700) 761252..761578 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
RJtmp_RS03530 (RJtmp_000701) 761490..761828 + 339 WP_003403405.1 PIN domain-containing protein -
RJtmp_RS03535 (RJtmp_000702) 761825..761998 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T178855 WP_003403386.1 NZ_CP063804:c758461-758024 [Mycobacterium orygis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T178855 NZ_CP084344:17648-17989 [Yersinia pestis]
ATGGTACTTTTTAGCCAGCGATTTGACGACTGGCTAAATGAGCAAGAAGACGCTCTTCAGGAAAAGGTTTTGGCTGATTT
GAAAAAGCTACAGGTTTACGGACCTGAGTTACCCAGGCCATATGCCGATACCGTGAAAGGTTCTCGGTACAAAAATATGA
AAGAGCTTCGCGTTCAGTTTTCTGGCCGTCCGATAAGAGCCTTTTATGCGTTCGATCCGATTCGTCGGGCTATCGTTCTT
TGTGCAGGAGATAAAAGTAATGATAAGCGGTTTTATGAAAAACTGGTGCGTATAGCTGAGGATGAATTTACAGCACATCT
GAACACACTGGAGAGCAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9450.99 Da        Isoelectric Point: 11.7073

>AT178855 WP_003911263.1 NZ_CP063804:c758712-758458 [Mycobacterium orygis]
MSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALR
ARRG

Download         Length: 255 bp

>AT178855 NZ_CP084344:17989-18288 [Yersinia pestis]
ATGAGAACATTAGATGAGGTGATTGCCAGTCGTTCACCTGAAAGCCAGACACGAATTAAAGAAATGGCAGATGAGATGAT
TCTTGAGGTCGGCTTGCAGATGATGCGTGAAGAACTCCAGTTATCACAAAAACAAGTTGCTGAGGCGATGGGTATAAGCC
AGCCAGCAGTAACAAAGCTGGAGCAGCGCGGAAATGATTTAAAGCTGGCGACGTTAAAGCGTTACGTTGAAGCAATGGGA
GGCAAATTAAGCTTGGATGTTGAGCTTCCTACAGGAAGGAGAGTAGCGTTCCATGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JQG1

References