Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 757374..757914 Replicon chromosome
Accession NZ_CP063804
Organism Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145

Toxin (Protein)


Gene name mazF Uniprot ID P9WII0
Locus tag RJtmp_RS03500 Protein ID WP_003403376.1
Coordinates 757374..757682 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag RJtmp_RS03505 Protein ID WP_003403381.1
Coordinates 757669..757914 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RJtmp_RS03475 (RJtmp_000690) 752689..754194 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
RJtmp_RS03480 (RJtmp_000691) 754275..755285 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
RJtmp_RS03485 (RJtmp_000692) 755673..756056 - 384 WP_003403365.1 ribonuclease VapC6 -
RJtmp_RS03490 (RJtmp_000693) 756151..756306 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
RJtmp_RS03495 (RJtmp_000694) 756382..757098 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
RJtmp_RS03500 (RJtmp_000695) 757374..757682 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
RJtmp_RS03505 (RJtmp_000696) 757669..757914 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
RJtmp_RS03510 (RJtmp_000697) 758024..758461 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
RJtmp_RS03515 (RJtmp_000698) 758458..758712 - 255 WP_003911263.1 antitoxin VapB7 -
RJtmp_RS03520 (RJtmp_000699) 758826..761189 + 2364 WP_003403397.1 arylsulfatase AtsD -
RJtmp_RS03525 (RJtmp_000700) 761252..761578 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
RJtmp_RS03530 (RJtmp_000701) 761490..761828 + 339 WP_003403405.1 PIN domain-containing protein -
RJtmp_RS03535 (RJtmp_000702) 761825..761998 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-101)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11320.10 Da        Isoelectric Point: 11.6554

>T178853 WP_003403376.1 NZ_CP063804:c757682-757374 [Mycobacterium orygis]
MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGLVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRR
ITRLSPARLHEACQTLRASTGC

Download         Length: 309 bp

>T178853 NZ_CP084343:c3580946-3580521 [Yersinia pestis]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT178853 WP_003403381.1 NZ_CP063804:c757914-757669 [Mycobacterium orygis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT178853 NZ_CP084343:c3581193-3580927 [Yersinia pestis]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSE5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References