Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 755673..756306 Replicon chromosome
Accession NZ_CP063804
Organism Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag RJtmp_RS03485 Protein ID WP_003403365.1
Coordinates 755673..756056 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag RJtmp_RS03490 Protein ID WP_003403368.1
Coordinates 756151..756306 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RJtmp_RS03460 (RJtmp_000687) 750965..751501 + 537 WP_003403341.1 50S ribosomal protein L10 -
RJtmp_RS03465 (RJtmp_000688) 751538..751930 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
RJtmp_RS03470 (RJtmp_000689) 751923..752618 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
RJtmp_RS03475 (RJtmp_000690) 752689..754194 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
RJtmp_RS03480 (RJtmp_000691) 754275..755285 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
RJtmp_RS03485 (RJtmp_000692) 755673..756056 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
RJtmp_RS03490 (RJtmp_000693) 756151..756306 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
RJtmp_RS03495 (RJtmp_000694) 756382..757098 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
RJtmp_RS03500 (RJtmp_000695) 757374..757682 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
RJtmp_RS03505 (RJtmp_000696) 757669..757914 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
RJtmp_RS03510 (RJtmp_000697) 758024..758461 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
RJtmp_RS03515 (RJtmp_000698) 758458..758712 - 255 WP_003911263.1 antitoxin VapB7 -
RJtmp_RS03520 (RJtmp_000699) 758826..761189 + 2364 WP_003403397.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T178852 WP_003403365.1 NZ_CP063804:c756056-755673 [Mycobacterium orygis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T178852 NZ_CP084343:c3564576-3564280 [Yersinia pestis]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT178852 WP_003403368.1 NZ_CP063804:c756306-756151 [Mycobacterium orygis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT178852 NZ_CP084343:c3564280-3563882 [Yersinia pestis]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References