Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 712937..713562 Replicon chromosome
Accession NZ_CP063804
Organism Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag RJtmp_RS03265 Protein ID WP_003403218.1
Coordinates 713161..713562 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag RJtmp_RS03260 Protein ID WP_003403213.1
Coordinates 712937..713164 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RJtmp_RS03235 (RJtmp_000642) 708116..708337 - 222 WP_003898525.1 DUF4926 domain-containing protein -
RJtmp_RS03240 (RJtmp_000643) 708479..709084 + 606 WP_003403205.1 hypothetical protein -
RJtmp_RS03245 (RJtmp_000644) 709103..711670 - 2568 WP_003403207.1 SEC-C metal-binding domain-containing protein -
RJtmp_RS03250 (RJtmp_000645) 711754..712503 + 750 WP_003898528.1 hypothetical protein -
RJtmp_RS03255 (RJtmp_000646) 712500..712742 + 243 WP_003403210.1 hypothetical protein -
RJtmp_RS03260 (RJtmp_000647) 712937..713164 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
RJtmp_RS03265 (RJtmp_000648) 713161..713562 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
RJtmp_RS03270 (RJtmp_000649) 713691..713774 + 84 Protein_648 galactose-1-phosphate uridylyltransferase -
RJtmp_RS03275 (RJtmp_000650) 713793..714875 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
RJtmp_RS03280 (RJtmp_000651) 714872..715963 + 1092 WP_003403225.1 galactokinase -
RJtmp_RS03285 (RJtmp_000652) 716358..717515 + 1158 WP_003403229.1 hypothetical protein -
RJtmp_RS03290 (RJtmp_000653) 717526..718473 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T178849 WP_003403218.1 NZ_CP063804:713161-713562 [Mycobacterium orygis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T178849 NZ_CP084343:2092229-2092322 [Yersinia pestis]
TAAGCCTACATTAATACCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATCAGGAATCGTA
TTCGGTCTTTTTTT

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT178849 WP_003403213.1 NZ_CP063804:712937-713164 [Mycobacterium orygis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT178849 NZ_CP084343:c2092323-2092229 [Yersinia pestis]
TAAAAAAAGACCGAATACGATTCCTGATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGT
ATTAATGTAGGCTTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References