Detailed information of TA system TA178844

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 444519..445530
• Replicon: chromosome
• Accession: NZ_CP063804
• Organism: Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: L7N5R2
• Locus tag: RJtmp_RS01940
• Protein ID: WP_003401859.1
• Coordinates: 444519..445112 (-)
• Length: 198 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: O53702
• Locus tag: RJtmp_RS01945
• Protein ID: WP_003401860.1
• Coordinates: 445141..445530 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RJtmp_RS01920 (RJtmp_000379)	440168..441550	+	1383	WP_003401854.1	magnesium transporter	-
RJtmp_RS01925 (RJtmp_000380)	441562..442596	-	1035	WP_003401856.1	class II fructose-bisphosphate aldolase	-
RJtmp_RS01930 (RJtmp_000381)	442692..443375	+	684	WP_003401857.1	VTT domain-containing protein	-
RJtmp_RS01935 (RJtmp_000382)	443364..444494	-	1131	WP_003401858.1	glycoside hydrolase family 76 protein	-
RJtmp_RS01940 (RJtmp_000383)	444519..445112	-	594	WP_003401859.1	zeta toxin family protein	Toxin
RJtmp_RS01945 (RJtmp_000384)	445141..445530	-	390	WP_003401860.1	hypothetical protein	Antitoxin
RJtmp_RS01950 (RJtmp_000385)	445611..446822	-	1212	WP_003401861.1	VWA domain-containing protein	-
RJtmp_RS01955 (RJtmp_000386)	446828..447430	-	603	WP_003898417.1	SRPBCC family protein	-
RJtmp_RS01960 (RJtmp_000387)	447444..448340	-	897	WP_003401863.1	MoxR family ATPase	-
RJtmp_RS01965 (RJtmp_000388)	448337..448930	-	594	WP_003401864.1	NTP transferase domain-containing protein	-
RJtmp_RS01970 (RJtmp_000389)	448927..449682	-	756	WP_003401865.1	XdhC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-156)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 198 a.a.
• Molecular weight: 21344.53 Da
• Isoelectric Point: 10.5018

>T178844 WP_003401859.1 NZ_CP063804:c445112-444519 [Mycobacterium orygis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Nucleotide

• Length: 594 bp

>T178844 NZ_CP084339:c3169321-3169025 [Yersinia pestis]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13648.21 Da
• Isoelectric Point: 6.0829

>AT178844 WP_003401860.1 NZ_CP063804:c445530-445141 [Mycobacterium orygis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Nucleotide

• Length: 390 bp

>AT178844 NZ_CP084339:c3169025-3168627 [Yersinia pestis]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Structures

Toxin

• AlphaFold DB: A0A7U4BRU8

Antitoxin

• AlphaFold DB: A0A7U4BRT0