Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 364710..365353 Replicon chromosome
Accession NZ_CP063804
Organism Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag RJtmp_RS01595 Protein ID WP_003401566.1
Coordinates 364928..365353 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag RJtmp_RS01590 Protein ID WP_003401563.1
Coordinates 364710..364931 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RJtmp_RS01565 (RJtmp_000313) 359931..360734 - 804 WP_003401540.1 Stf0 family sulphotransferase -
RJtmp_RS01570 (RJtmp_000314) 360744..362141 - 1398 WP_003401544.1 sulfatase -
RJtmp_RS01575 (RJtmp_000315) 362320..363993 + 1674 WP_140035357.1 PE family protein -
RJtmp_RS01580 (RJtmp_000316) 364136..364363 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
RJtmp_RS01585 (RJtmp_000317) 364360..364662 + 303 WP_003401560.1 toxin-antitoxin system toxin -
RJtmp_RS01590 (RJtmp_000318) 364710..364931 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
RJtmp_RS01595 (RJtmp_000319) 364928..365353 + 426 WP_003401566.1 PIN domain nuclease Toxin
RJtmp_RS01600 (RJtmp_000320) 365489..366121 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
RJtmp_RS01605 (RJtmp_04050) 366013..368643 - 2631 WP_003401573.1 PPE family protein -
RJtmp_RS01610 (RJtmp_04055) 368757..368906 - 150 WP_232425631.1 pentapeptide repeat-containing protein -
RJtmp_RS01615 (RJtmp_04060) 369508..369753 - 246 Protein_319 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T178843 WP_003401566.1 NZ_CP063804:364928-365353 [Mycobacterium orygis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T178843 NZ_CP084339:c2323859-2323766 [Yersinia pestis]
TAAGCCTACATTAATACCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATCAGGAATCGTA
TTCGGTCTTTTTTT

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT178843 WP_003401563.1 NZ_CP063804:364710-364931 [Mycobacterium orygis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT178843 NZ_CP084339:2323765-2323859 [Yersinia pestis]
TAAAAAAAGACCGAATACGATTCCTGATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGT
ATTAATGTAGGCTTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References