Detailed information of TA system TA178841

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 364136..364662
• Replicon: chromosome
• Accession: NZ_CP063804
• Organism: Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: -
• Locus tag: RJtmp_RS01585
• Protein ID: WP_003401560.1
• Coordinates: 364360..364662 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: P9WJ08
• Locus tag: RJtmp_RS01580
• Protein ID: WP_003401555.1
• Coordinates: 364136..364363 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RJtmp_RS01560 (RJtmp_000312)	359157..359942	+	786	WP_003401538.1	trans-aconitate 2-methyltransferase	-
RJtmp_RS01565 (RJtmp_000313)	359931..360734	-	804	WP_003401540.1	Stf0 family sulphotransferase	-
RJtmp_RS01570 (RJtmp_000314)	360744..362141	-	1398	WP_003401544.1	sulfatase	-
RJtmp_RS01575 (RJtmp_000315)	362320..363993	+	1674	WP_140035357.1	PE family protein	-
RJtmp_RS01580 (RJtmp_000316)	364136..364363	+	228	WP_003401555.1	ribbon-helix-helix protein, CopG family	Antitoxin
RJtmp_RS01585 (RJtmp_000317)	364360..364662	+	303	WP_003401560.1	toxin-antitoxin system toxin	Toxin
RJtmp_RS01590 (RJtmp_000318)	364710..364931	+	222	WP_003401563.1	type II toxin-antitoxin system antitoxin VapB2	-
RJtmp_RS01595 (RJtmp_000319)	364928..365353	+	426	WP_003401566.1	PIN domain nuclease	-
RJtmp_RS01600 (RJtmp_000320)	365489..366121	+	633	WP_003401571.1	TetR/AcrR family transcriptional regulator	-
RJtmp_RS01605 (RJtmp_04050)	366013..368643	-	2631	WP_003401573.1	PPE family protein	-
RJtmp_RS01610 (RJtmp_04055)	368757..368906	-	150	WP_232425631.1	pentapeptide repeat-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10442.16 Da
• Isoelectric Point: 4.9609

>T178841 WP_003401560.1 NZ_CP063804:364360-364662 [Mycobacterium orygis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Nucleotide

• Length: 303 bp

>T178841 NZ_CP084339:c1660731-1660273 [Yersinia pestis]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8130.21 Da
• Isoelectric Point: 7.0084

>AT178841 WP_003401555.1 NZ_CP063804:364136-364363 [Mycobacterium orygis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Nucleotide

• Length: 228 bp

>AT178841 NZ_CP084339:c1661239-1660793 [Yersinia pestis]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4F8T1