Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 71355..71988 Replicon chromosome
Accession NZ_CP063804
Organism Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145

Toxin (Protein)


Gene name vapC Uniprot ID P9WFC0
Locus tag RJtmp_RS00360 Protein ID WP_003400580.1
Coordinates 71587..71988 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P0CW29
Locus tag RJtmp_RS00355 Protein ID WP_003400577.1
Coordinates 71355..71594 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RJtmp_RS00340 (RJtmp_000068) 66652..68091 + 1440 Protein_64 FAD-binding oxidoreductase -
RJtmp_RS00345 (RJtmp_000069) 68147..68308 + 162 WP_003899796.1 hypothetical protein -
RJtmp_RS00350 (RJtmp_000070) 68349..71288 + 2940 WP_003901785.1 UPF0182 family protein -
RJtmp_RS00355 (RJtmp_000071) 71355..71594 + 240 WP_003400577.1 antitoxin VapB1 Antitoxin
RJtmp_RS00360 (RJtmp_000072) 71587..71988 + 402 WP_003400580.1 type II toxin-antitoxin system ribonuclease VapC1 Toxin
RJtmp_RS00365 (RJtmp_000073) 72040..74277 - 2238 WP_003400583.1 NADP-dependent isocitrate dehydrogenase -
RJtmp_RS00370 (RJtmp_000074) 74395..74964 - 570 WP_249739990.1 TetR/AcrR family transcriptional regulator -
RJtmp_RS00375 (RJtmp_000075) 75067..75975 + 909 Protein_71 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(36-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14339.44 Da        Isoelectric Point: 4.8887

>T178840 WP_003400580.1 NZ_CP063804:71587-71988 [Mycobacterium orygis]
VDECVVDAAAVVDALAGKGASAIVLRGLLKESISNAPHLLDAEVGHALRRAVLSDEISEEQARAALDALPYLIDNRYPHS
PRLIEYTWQLRHNVTFYDALYVALATALDVPLLTGDSRLAAAPGLPCEIKLVR

Download         Length: 402 bp

>T178840 NZ_CP084339:c715456-715253 [Yersinia pestis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8717.84 Da        Isoelectric Point: 8.5960

>AT178840 WP_003400577.1 NZ_CP063804:71355-71594 [Mycobacterium orygis]
MATIQVRDLPEDVAETYRRRATAAGQSLQTYMRTKLIEGVRGRDKAEAIEILEQALASTASPGISRETIEASRRELRGG

Download         Length: 240 bp

>AT178840 NZ_CP084339:c715873-715505 [Yersinia pestis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BR82

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHM7

References