Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/GNAT-DUF1778
Location 34753..35583 Replicon plasmid unnamed4
Accession NZ_CP063789
Organism Tolypothrix sp. PCC 7712

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0D6KD35
Locus tag HGR01_RS39450 Protein ID WP_045874276.1
Coordinates 34753..35271 (-) Length 173 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0D6KC66
Locus tag HGR01_RS39455 Protein ID WP_045874275.1
Coordinates 35275..35583 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGR01_RS39415 (HGR01_38280) 29838..31484 + 1647 WP_096622410.1 DDE-type integrase/transposase/recombinase -
HGR01_RS39420 (HGR01_38285) 31474..32445 + 972 WP_045874280.1 AAA family ATPase -
HGR01_RS39425 (HGR01_38290) 32648..32806 - 159 WP_194007727.1 hypothetical protein -
HGR01_RS39430 32848..32957 + 110 Protein_21 arsenate reductase -
HGR01_RS39435 (HGR01_38295) 33179..33820 + 642 WP_071989483.1 site-specific integrase -
HGR01_RS39440 (HGR01_38300) 34042..34404 + 363 WP_045874278.1 type II toxin-antitoxin system RelE/ParE family toxin -
HGR01_RS39445 (HGR01_38305) 34401..34730 + 330 WP_045874277.1 XRE family transcriptional regulator -
HGR01_RS39450 (HGR01_38310) 34753..35271 - 519 WP_045874276.1 GNAT family N-acetyltransferase Toxin
HGR01_RS39455 (HGR01_38315) 35275..35583 - 309 WP_045874275.1 DUF1778 domain-containing protein Antitoxin
HGR01_RS39460 (HGR01_38320) 35681..38074 - 2394 WP_045874274.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..92234 92234


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(51-149)

Antitoxin

Vibrio phage ICP1, Orf50

(17-91)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 18504.33 Da        Isoelectric Point: 7.8456

>T178839 WP_045874276.1 NZ_CP063789:c35271-34753 [Tolypothrix sp. PCC 7712]
VTGSQEQQIQAPEPLNAEHQLENFDSGNAELDEWLKKRALKNEASGASRTYVVTVGQKAIAYYCLANGSVINTTAPGKVR
RNMPDPIPVMVIGRLAVDINWQGQGLGYALVRDAVLRTLQAAKIAGIRAILVHAISVEAKQFYEKCGFIPSPVAPMTLMV
TIADALQAFGVG

Download         Length: 519 bp

>T178839 NZ_CP084338:c13721-13422 [Yersinia pestis]
GTGTATAAACTGTCTGAACTAGCTGATGAGGATATTTATAATATTGCCAGTTATACTATCCGGCATTTCGGTGTGACTCA
GGCTAAGTTATACCATGAGAACTTGGCAAAGGTATTCGAGCTATTAGCTAAAAATCCAGAGTTAGGGGCTGAGTGTAACT
GGATTTGCTCTGATATTCGCCGTTTTCAGTATAAAAAGCACGGTATATACTATATAACGCTTAGCAATGATATTTTGATT
TCTCGAGTGCTGCATCAATCCATAGATATAGATGTTCAGGATTTTCCAGAGCATGAGTAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11647.12 Da        Isoelectric Point: 5.7287

>AT178839 WP_045874275.1 NZ_CP063789:c35583-35275 [Tolypothrix sp. PCC 7712]
MQPQTGSSNHQNRDVTINIRAHQGQRDLIDRAAEALGKNRSDFMLETACREAEAVLLDRRLFMLDDEKFQQFVELLDQPP
ATNANLRKLLTKKAPWEQGVGE

Download         Length: 309 bp

>AT178839 NZ_CP084338:c13956-13714 [Yersinia pestis]
ATGGCTCACGTAACCAGCGTAACACTTGGAGAGCATTTGACAGGTTTTGTGGGGGAAATGATTCAGTCTGGTCGTTATGG
CAATATATCAGAAGTGCTTCGTGATGCCTTAAGGCTAATGGAAGCACGTGAACAGCGTGTTCAACATGTACGCGATATGG
TGCTTGCAGGAACAAATGTACCTGTGAGCCATCGTTTAATGGATGAGATTTTTTCTGCTGCGGTGAAAGATACTAGTGTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6KD35

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6KC66

References