Detailed information of TA system TA178838

Bioinformatically predicted

Overview

TA module

• Type: VII
• Classification (family/domain): HepT-MntA/HepT(toxin)
• Location: 5903023..5903915
• Replicon: chromosome
• Accession: NZ_CP063785
• Organism: Tolypothrix sp. PCC 7712

Toxin (Protein)

• Gene name: hepT
• Uniprot ID: -
• Locus tag: HGR01_RS24235
• Protein ID: WP_052335210.1
• Coordinates: 5903023..5903466 (-)
• Length: 148 a.a.

Antitoxin (Protein)

• Gene name: mntA
• Uniprot ID: A0A0D6KQU4
• Locus tag: HGR01_RS24240
• Protein ID: WP_045870813.1
• Coordinates: 5903463..5903915 (-)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGR01_RS24225 (HGR01_23485)	5898588..5899598	-	1011	WP_045870815.1	type I-D CRISPR-associated protein Cas7/Csc2	-
HGR01_RS24230 (HGR01_23490)	5899668..5903030	-	3363	WP_045870814.1	type I-D CRISPR-associated protein Cas10d/Csc3	-
HGR01_RS24235 (HGR01_23495)	5903023..5903466	-	444	WP_052335210.1	DUF86 domain-containing protein	Toxin
HGR01_RS24240 (HGR01_23500)	5903463..5903915	-	453	WP_045870813.1	nucleotidyltransferase domain-containing protein	Antitoxin
HGR01_RS24245 (HGR01_23505)	5903974..5904993	-	1020	WP_045870812.1	PDDEXK nuclease domain-containing protein	-
HGR01_RS24250 (HGR01_23510)	5905026..5905229	-	204	WP_045870811.1	DUF433 domain-containing protein	-
HGR01_RS24255 (HGR01_23515)	5905444..5905647	-	204	WP_045870810.1	hypothetical protein	-
HGR01_RS24260 (HGR01_23520)	5905928..5908105	-	2178	WP_045870809.1	type I-D CRISPR-associated helicase Cas3'	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease HepT-like (17-132)

Antitoxin

• Polymerase beta, nucleotidyltransferase (21-112)

Sequences

Toxin

Protein

• Length: 148 a.a.
• Molecular weight: 16906.12 Da
• Isoelectric Point: 4.4596

>T178838 WP_052335210.1 NZ_CP063785:c5903466-5903023 [Tolypothrix sp. PCC 7712]
MKNIDTVIVTTRLEFIARYLDNLKRFEAITWDDYLNNIDNQLITERLLQLMAQAAIDINDHILSKLNPGNSNTNFEAFIE
LGNYGVITPELAKQLAPSSGLRNRLVHEYDDIDPQQVFRAISFALQQYPLYVRQVNSYLISLSEENG

Nucleotide

• Length: 444 bp

>T178838 NZ_CP084337:c128407-128066 [Yersinia pestis]
ATGGTACTTTTTAGCCAGCGATTTGACGACTGGCTAAATGAGCAAGAAGACGCTCTTCAGGAAAAGGTTTTGGCTGATTT
GAAAAAGCTACAGGTTTACGGACCTGAGTTACCCAGGCCATATGCCGATACCGTGAAAGGTTCTCGGTACAAAAATATGA
AAGAGCTTCGCGTTCAGTTTTCTGGCCGTCCGATAAGAGCCTTTTATGCGTTCGATCCGATTCGTCGGGCTATCGTTCTT
TGTGCAGGAGATAAAAGTAATGATAAGCGGTTTTATGAAAAACTGGTGCGTATAGCTGAGGATGAATTTACAGCACATCT
GAACACACTGGAGAGCAAGTAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 17359.02 Da
• Isoelectric Point: 5.3217

>AT178838 WP_045870813.1 NZ_CP063785:c5903915-5903463 [Tolypothrix sp. PCC 7712]
MQNHTPTITELQELALQLPEKIPYLKMLVLFGSRATGNANAKSDWDFAVLCDEEQREAYIKNNISGLFELPMLIGEVLKI
NSDKIDIVELNHCSELIAHFVARDGKVLYESEAEEFEKFKQKVLLSKSELKKIEHIKRQNIEQFLQRWGV

Nucleotide

• Length: 453 bp

>AT178838 NZ_CP084337:c128066-127767 [Yersinia pestis]
ATGAGAACATTAGATGAGGTGATTGCCAGTCGTTCACCTGAAAGCCAGACACGAATTAAAGAAATGGCAGATGAGATGAT
TCTTGAGGTCGGCTTGCAGATGATGCGTGAAGAACTCCAGTTATCACAAAAACAAGTTGCTGAGGCGATGGGTATAAGCC
AGCCAGCAGTAACAAAGCTGGAGCAGCGCGGAAATGATTTAAAGCTGGCGACGTTAAAGCGTTACGTTGAAGCAATGGGA
GGCAAATTAAGCTTGGATGTTGAGCTTCCTACAGGAAGGAGAGTAGCGTTCCATGTCTAA

Structures

Antitoxin

• AlphaFold DB: A0A0D6KQU4