Detailed information of TA system TA178837

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 5303777..5304405
• Replicon: chromosome
• Accession: NZ_CP063785
• Organism: Tolypothrix sp. PCC 7712

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HGR01_RS21805
• Protein ID: WP_263420001.1
• Coordinates: 5304100..5304405 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0D6KDR9
• Locus tag: HGR01_RS21800
• Protein ID: WP_045874043.1
• Coordinates: 5303777..5304004 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGR01_RS21765	5298997..5299170	+	174	WP_168161041.1	hypothetical protein	-
HGR01_RS21770 (HGR01_21140)	5299258..5301705	+	2448	WP_045874048.1	VIT domain-containing protein	-
HGR01_RS21775 (HGR01_21145)	5302020..5302199	-	180	WP_155539613.1	hypothetical protein	-
HGR01_RS21780 (HGR01_21150)	5302875..5303090	+	216	WP_155539611.1	hypothetical protein	-
HGR01_RS21785	5303091..5303213	+	123	WP_264263282.1	hypothetical protein	-
HGR01_RS21790 (HGR01_21155)	5303224..5303463	+	240	WP_045874044.1	hypothetical protein	-
HGR01_RS21795 (HGR01_21160)	5303435..5303662	+	228	WP_096621716.1	hypothetical protein	-
HGR01_RS21800 (HGR01_21165)	5303777..5304004	+	228	WP_045874043.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
HGR01_RS21805 (HGR01_21170)	5304100..5304405	+	306	WP_263420001.1	type II toxin-antitoxin system VapC family toxin	Toxin
HGR01_RS21810	5304713..5304844	+	132	WP_255325363.1	hypothetical protein	-
HGR01_RS21815 (HGR01_21175)	5305002..5305208	-	207	WP_155539609.1	hypothetical protein	-
HGR01_RS21820 (HGR01_21180)	5305360..5306649	+	1290	WP_045874041.1	phosphoribosylamine--glycine ligase	-
HGR01_RS21825 (HGR01_21185)	5306928..5308823	+	1896	WP_045874040.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11052.83 Da
• Isoelectric Point: 4.4797

>T178837 WP_263420001.1 NZ_CP063785:5304100-5304405 [Tolypothrix sp. PCC 7712]
VGISSITVAELEYGVAKSQQQEKNRTALLQFLLPLEIVDFNPTAATIYGSIRSDLETRGIIIGAMDMLIAAHALSLGVIL
VTNNLREFSRIPALLLENWVD

Nucleotide

• Length: 306 bp

>T178837 NZ_CP084336:c3184931-3184506 [Yersinia pestis]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8471.55 Da
• Isoelectric Point: 4.1630

>AT178837 WP_045874043.1 NZ_CP063785:5303777-5304004 [Tolypothrix sp. PCC 7712]
MNTAKLSTDGTHQVVILPEDFQLTGTEVYIKKIGNAIILIAKDNSWQSLIESLDNFSDDFMTTREQPLIDTRESL

Nucleotide

• Length: 228 bp

>AT178837 NZ_CP084336:c3185178-3184912 [Yersinia pestis]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0D6KDR9