Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 4545001..4545610 Replicon chromosome
Accession NZ_CP063785
Organism Tolypothrix sp. PCC 7712

Toxin (Protein)


Gene name relE Uniprot ID A0A0D6KBC2
Locus tag HGR01_RS18780 Protein ID WP_045874609.1
Coordinates 4545248..4545610 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D6KB47
Locus tag HGR01_RS18775 Protein ID WP_045874651.1
Coordinates 4545001..4545258 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGR01_RS18765 (HGR01_18180) 4540620..4544186 - 3567 WP_096621646.1 CHAT domain-containing protein -
HGR01_RS18770 (HGR01_18185) 4544328..4544876 + 549 WP_096621648.1 diheme cytochrome c -
HGR01_RS18775 (HGR01_18190) 4545001..4545258 + 258 WP_045874651.1 hypothetical protein Antitoxin
HGR01_RS18780 (HGR01_18195) 4545248..4545610 + 363 WP_045874609.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HGR01_RS18785 (HGR01_18200) 4545965..4548757 + 2793 WP_045874608.1 preprotein translocase subunit SecA -
HGR01_RS18790 (HGR01_18205) 4548867..4549508 - 642 WP_045874607.1 Uma2 family endonuclease -
HGR01_RS18795 (HGR01_18210) 4549591..4550292 - 702 WP_045874606.1 carbonic anhydrase -
HGR01_RS18800 (HGR01_18215) 4550289..4550600 - 312 WP_045874605.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(36-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13806.48 Da        Isoelectric Point: 4.7613

>T178836 WP_045874609.1 NZ_CP063785:4545248-4545610 [Tolypothrix sp. PCC 7712]
MQSDNTVSIRFADEFEEKLYRLSKRFRNIRSDVQPIIEQLQQGNIVGDRISGLGEEYIVYKVRVRNSNIQKGKSGGYRLI
YQLESPTSILLLTIYSKSDQEDIAANEIRNILADFDSEEG

Download         Length: 363 bp

>T178836 NZ_CP084336:c3170521-3170225 [Yersinia pestis]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9527.83 Da        Isoelectric Point: 4.4169

>AT178836 WP_045874651.1 NZ_CP063785:4545001-4545258 [Tolypothrix sp. PCC 7712]
MKAIEVTGKIDAQGNLILDEPIHGTTYPHQVRVIVLVPEPAETEELDPDDTPVEEIKASLRRALKQAKMGQTRPISELWD
RIDAE

Download         Length: 258 bp

>AT178836 NZ_CP084336:c3170225-3169827 [Yersinia pestis]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6KBC2

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6KB47

References