Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 80335..80956 Replicon chromosome
Accession NZ_CP063785
Organism Tolypothrix sp. PCC 7712

Toxin (Protein)


Gene name relE Uniprot ID A0A0D6L286
Locus tag HGR01_RS00330 Protein ID WP_045867782.1
Coordinates 80570..80956 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D6L188
Locus tag HGR01_RS00325 Protein ID WP_045867781.1
Coordinates 80335..80577 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGR01_RS00290 (HGR01_00290) 75441..75671 - 231 WP_045867774.1 hypothetical protein -
HGR01_RS00295 (HGR01_00295) 75738..76136 + 399 WP_045867775.1 metal-sensitive transcriptional regulator -
HGR01_RS00300 (HGR01_00300) 76209..77018 + 810 WP_045867776.1 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase -
HGR01_RS00305 (HGR01_00305) 77225..78523 - 1299 WP_045867777.1 glutamate-1-semialdehyde 2,1-aminomutase -
HGR01_RS00310 (HGR01_00310) 78632..78820 + 189 WP_045867778.1 ChaB family protein -
HGR01_RS00315 (HGR01_00315) 78922..79572 + 651 WP_045867779.1 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE -
HGR01_RS00320 (HGR01_00320) 79620..80201 + 582 WP_045867780.1 Uma2 family endonuclease -
HGR01_RS00325 (HGR01_00325) 80335..80577 + 243 WP_045867781.1 hypothetical protein Antitoxin
HGR01_RS00330 (HGR01_00330) 80570..80956 + 387 WP_045867782.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HGR01_RS00335 (HGR01_00335) 81033..83096 - 2064 WP_081583873.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(20-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14526.40 Da        Isoelectric Point: 5.1813

>T178834 WP_045867782.1 NZ_CP063785:80570-80956 [Tolypothrix sp. PCC 7712]
MVDRPLIQVDASLTFNRNIRTLAKKYRSIRNDIQPVIEQLQQGELPGDQIPGVGYTVFKLRVRNSDTQKGKSGGYRLIYY
VKTATGIILLTIYTKSEQVDIAADDIQSIITDYEQRTLTEQDDISDNS

Download         Length: 387 bp

>T178834 NZ_CP084336:2292390-2292572 [Yersinia pestis]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8944.13 Da        Isoelectric Point: 3.9689

>AT178834 WP_045867781.1 NZ_CP063785:80335-80577 [Tolypothrix sp. PCC 7712]
MKALKVMATINDQGQLTLDHPLLTDKNSRVEVIVLIPDEEVVLDDQSQAEVLADFRQAWHEAMTGQTIPVAQMWEGLEDG

Download         Length: 243 bp

>AT178834 NZ_CP084336:2292617-2293036 [Yersinia pestis]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6L286

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6L188

References