Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1963842..1964457 Replicon chromosome
Accession NZ_CP063780
Organism Pseudomonas sp. OST1909

Toxin (Protein)


Gene name hicA Uniprot ID I4KFU3
Locus tag IH404_RS08550 Protein ID WP_003189411.1
Coordinates 1964275..1964457 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID I4KSL1
Locus tag IH404_RS08545 Protein ID WP_005785962.1
Coordinates 1963842..1964252 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IH404_RS08510 1959393..1959869 - 477 WP_005785951.1 DMT family transporter -
IH404_RS08515 1959938..1960864 + 927 WP_032803808.1 LysR family transcriptional regulator -
IH404_RS08520 1960880..1961296 + 417 WP_194440279.1 fosfomycin resistance glutathione transferase -
IH404_RS08525 1961344..1961985 + 642 WP_005785956.1 LysE family translocator -
IH404_RS08530 1962104..1962631 + 528 WP_005785958.1 DUF4142 domain-containing protein -
IH404_RS08535 1962684..1963100 - 417 WP_005785960.1 low affinity iron permease family protein -
IH404_RS08540 1963202..1963702 - 501 WP_122735493.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
IH404_RS08545 1963842..1964252 - 411 WP_005785962.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IH404_RS08550 1964275..1964457 - 183 WP_003189411.1 type II toxin-antitoxin system HicA family toxin Toxin
IH404_RS08555 1964625..1965518 - 894 WP_194440280.1 LysR family transcriptional regulator -
IH404_RS08560 1965614..1966783 + 1170 WP_005785966.1 MFS transporter -
IH404_RS08570 1967063..1967947 - 885 WP_005785967.1 alpha/beta hydrolase -
IH404_RS08575 1968251..1968943 - 693 WP_005785968.1 pseudouridine synthase -
IH404_RS08580 1968933..1969145 - 213 WP_005785969.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6804.01 Da        Isoelectric Point: 10.7532

>T178830 WP_003189411.1 NZ_CP063780:c1964457-1964275 [Pseudomonas sp. OST1909]
VDSRYLIGHIVADGWYLVRIRGSHHHFKHPTKPGLVTIPHPKKDLLDKTAKSILKQALLS

Download         Length: 183 bp

>T178830 NZ_CP084321:c6021707-6021429 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTTGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14785.70 Da        Isoelectric Point: 4.2941

>AT178830 WP_005785962.1 NZ_CP063780:c1964252-1963842 [Pseudomonas sp. OST1909]
MLYPIAISTGDEDHAWGVEVPDIPGCYSAGDDLDDAMAMAREAIEGHFEILAEDGAPIPCAQKVTLHAANPQYAGCTWAV
VDIDVTKYLGKAQKLNITLPGYLLNRIDDYVLNHPEEKSRSGFLASAALKVLQQDR

Download         Length: 411 bp

>AT178830 NZ_CP084321:c6021417-6021112 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X7DFI9

Antitoxin

Source ID Structure
AlphaFold DB A0A7S7MX63

References