Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4103379..4103997 Replicon chromosome
Accession NZ_CP063774
Organism Escherichia coli O25b:H4-ST131

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag INT78_RS19560 Protein ID WP_001291435.1
Coordinates 4103379..4103597 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag INT78_RS19565 Protein ID WP_000344800.1
Coordinates 4103623..4103997 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INT78_RS19525 4098666..4099238 + 573 WP_000779831.1 YbaY family lipoprotein -
INT78_RS19530 4099269..4099580 - 312 WP_000409908.1 MGMT family protein -
INT78_RS19540 4099959..4100312 + 354 WP_000878135.1 DUF1428 family protein -
INT78_RS19545 4100354..4101904 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
INT78_RS19550 4102068..4102538 - 471 WP_000136192.1 YlaC family protein -
INT78_RS19555 4102654..4103205 - 552 WP_000102539.1 maltose O-acetyltransferase -
INT78_RS19560 4103379..4103597 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
INT78_RS19565 4103623..4103997 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
INT78_RS19570 4104543..4107692 - 3150 WP_001132478.1 multidrug efflux RND transporter permease subunit -
INT78_RS19575 4107715..4108908 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T178814 WP_001291435.1 NZ_CP063774:c4103597-4103379 [Escherichia coli O25b:H4-ST131]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T178814 NZ_CP084312:1216098-1216400 [Bifidobacterium pseudolongum]
ATGGAGATTCGTACTACTGAGCAATTCGATAAATGGTTCCGCAAGTTGCGGGACCGCAAAGCAAAAGCCAAAATCAGCGC
ACGGCTCAGACAATGCGAAATCTCCGACCATATCACTGGAGATCATCATGGCATCGGCGGTGGCATAAGTGAAATGAGAT
TCCATTTTGGACCGGGATATCGTATCTACTACACCGTTGACAATGATGTGCTTGTTATTTTACTGATCGGAAGTGGTAAA
GACGATCAGTCCAGAGGGATTGCCGAAGCGAGAAAACTTCTTGCTTTATATCGAGGAGAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT178814 WP_000344800.1 NZ_CP063774:c4103997-4103623 [Escherichia coli O25b:H4-ST131]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT178814 NZ_CP084312:1216402-1216695 [Bifidobacterium pseudolongum]
ATGACGCTTAAAACCACCAAATGGGATGTTACGGAATATCTTGATAATGAAGAGGATATCGCCGAATACCTCAACGCAGT
AATCGAATTGGACGATCCTGCGTTGCTCCAAGCTGCTATTGGTGATGTTGCCAAGGCGCAGGGGATGACGAAAATCGCCA
AAGATGCAGGCCTAGGCAGAGAAAGCCTATATAAAAGTCTGAGTGCACAAGGCAATCCTTCTTTCACGACCATATTGAAA
GTACTGCATGCTCTCGGTACAAGAATCAGCATTCAACCAGAACACGCTATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References