Detailed information of TA system TA178813

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3919001..3920690
• Replicon: chromosome
• Accession: NZ_CP063774
• Organism: Escherichia coli O25b:H4-ST131

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: INT78_RS18705
• Protein ID: WP_000365807.1
• Coordinates: 3919770..3920690 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: INT78_RS18700
• Protein ID: WP_001295795.1
• Coordinates: 3919001..3919783 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INT78_RS18695	3915619..3918717	-	3099	WP_000673070.1	type I restriction endonuclease subunit R	-
INT78_RS18700	3919001..3919783	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
INT78_RS18705	3919770..3920690	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
INT78_RS18710	3920855..3922174	-	1320	Protein_3650	site-specific integrase	-
INT78_RS18715	3922401..3922559	-	159	Protein_3651	integrase	-
INT78_RS18720	3922608..3922793	+	186	WP_000146240.1	hypothetical protein	-
INT78_RS18725	3923008..3923622	+	615	WP_001019923.1	YagU family protein	-
INT78_RS18730	3923696..3923859	+	164	Protein_3654	tail fiber assembly protein	-
INT78_RS18735	3923871..3924200	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
INT78_RS18740	3924507..3925217	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	3912751..3960906	48155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T178813 WP_000365807.1 NZ_CP063774:3919770-3920690 [Escherichia coli O25b:H4-ST131]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

>T178813 NZ_CP084303:c7631-7338 [Acinetobacter pseudolwoffii]
ATGACTTATAAGCTTTTACGTCATAAGGACTTCACTGCAGAATGGGAAAAGCTTCCTAGTGCTATACGAGATCAATTCAA
GAAAAAATTAGCTAAGGTAATAGAGCAACCACATATTCCAAAGAATATGCTTAAAGGTGATCTTGCAGGCTGCTATAAAA
TAAAATTATTAAAAGCTGGTGTCCGACTTGTTTACCAGGTCAAAGATGATCAGGTAGTTATTTTGCTAATTACCGTTGGA
AAACGAGCTGATAGCATTGTTTATGATGAAGCAAAAAAGCGGATAAAAGACTAA

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT178813 WP_001295795.1 NZ_CP063774:3919001-3919783 [Escherichia coli O25b:H4-ST131]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

>AT178813 NZ_CP084303:c7866-7621 [Acinetobacter pseudolwoffii]
ATGGCTACTGTTAATTTCAGGGTCGATGAAGCCCTTAAAGAAAAGTCTTATTCCATCCTAAAAGAACAAGGAATTGCACC
TACTGAGTTCTTTACTAATATTCTTGAATATATTGCTACGACTGGAAAGCTTCCAGTACAAAAAGCTTTACTCTCAGAAG
AGGATACCGAGCTATTAGCGATTGTTCGTAAACGTGTTAATGATCCTAAAGAGATGTTCGAGGAAGTCACATTAGATGAC
TTATAA

Structures

Toxin

• AlphaFold DB: A0A061KTE0