178808

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3597360..3597880 Replicon chromosome
Accession NZ_CP063774
Organism Escherichia coli O25b:H4-ST131

Toxin (Protein)


Gene name ccdB Uniprot ID A0A061KX66
Locus tag INT78_RS17090 Protein ID WP_001160964.1
Coordinates 3597596..3597880 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag INT78_RS17085 Protein ID WP_000125566.1
Coordinates 3597360..3597593 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INT78_RS17060 3592433..3592720 + 288 WP_000203744.1 ferredoxin-like protein FixX -
INT78_RS17065 3592779..3594110 + 1332 WP_001183209.1 MFS transporter -
INT78_RS17070 3594218..3594748 + 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
INT78_RS17075 3594741..3596603 + 1863 WP_000377106.1 glutathione-regulated potassium-efflux system protein KefC -
INT78_RS17080 3596795..3597274 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
INT78_RS17085 3597360..3597593 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
INT78_RS17090 3597596..3597880 + 285 WP_001160964.1 CcdB family protein Toxin
INT78_RS17095 3597907..3598755 - 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
INT78_RS17100 3598762..3599139 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
INT78_RS17105 3599142..3599963 - 822 WP_001065365.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
INT78_RS17110 3599960..3600949 - 990 WP_000241227.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
INT78_RS17115 3600949..3602235 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-93)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10692.54 Da        Isoelectric Point: 10.3030

>T178808 WP_001160964.1 NZ_CP063774:3597596-3597880 [Escherichia coli O25b:H4-ST131]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLIDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIK

Download         Length: 285 bp

>T178808 NZ_CP084302:21609-21890 [Acinetobacter pseudolwoffii]
ATGGCTATTAAACTTCGCAAATGGGACAGTGCTGAGCATCTTAAAACAGAGGATGATATGCAGGCTTACTTACAAGCATG
TATTGAAGAATCTAATGGCGATGCCGCATTCATTGCAAAGGCTTTAGGTAACATTGCAAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGCTTAGGCCGAGAAAGTCTTTATAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT178808 WP_000125566.1 NZ_CP063774:3597360-3597593 [Escherichia coli O25b:H4-ST131]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT178808 NZ_CP084302:21306-21608 [Acinetobacter pseudolwoffii]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTCACCAAGTTAAAAGACCAGCAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAGCCGGTCGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGGCCAGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTTGTTATTCTTTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTGCAATTGGCACAAGATTTAGAGGAGGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061KX66

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References