Detailed information of TA system TA178806

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3437637..3438457
• Replicon: chromosome
• Accession: NZ_CP063774
• Organism: Escherichia coli O25b:H4-ST131

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: INT78_RS16330
• Protein ID: WP_001054379.1
• Coordinates: 3438200..3438457 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: INT78_RS16325
• Protein ID: WP_000123957.1
• Coordinates: 3437637..3438188 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INT78_RS16295	3433331..3434644	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
INT78_RS16300	3434656..3434934	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
INT78_RS16305	3434931..3436052	-	1122	WP_000010833.1	M42 family metallopeptidase	-
INT78_RS16310	3436297..3436413	-	117	Protein_3181	VOC family protein	-
INT78_RS16315	3436451..3436711	-	261	WP_000077645.1	hypothetical protein	-
INT78_RS16320	3436839..3437585	-	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
INT78_RS16325	3437637..3438188	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
INT78_RS16330	3438200..3438457	-	258	WP_001054379.1	YjhX family toxin	Toxin
INT78_RS16335	3438834..3438998	-	165	Protein_3186	GNAT family N-acetyltransferase	-
INT78_RS16345	3440304..3441347	+	1044	WP_001363826.1	hypothetical protein	-
INT78_RS16350	3441930..3442910	-	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T178806 WP_001054379.1 NZ_CP063774:c3438457-3438200 [Escherichia coli O25b:H4-ST131]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T178806 NZ_CP084302:18463-18750 [Acinetobacter pseudolwoffii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCGATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATACGAATCATTAGT
GCAAGGCAAGTGACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT178806 WP_000123957.1 NZ_CP063774:c3438188-3437637 [Escherichia coli O25b:H4-ST131]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT178806 NZ_CP084302:18737-19051 [Acinetobacter pseudolwoffii]
ATGAGCATGGTTAGATACTCACGCAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACCGATTGGAGCAGTGCTGTACGCC
AAAATCAATTTTACCGCCCAGTGAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGAATGAATGAAATTTTACGGGATGCTATGCTGAAAGAATTAAAAAATCATCAATAA

Structures

Toxin

• AlphaFold DB: B6I030