Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1855864..1856698 | Replicon | chromosome |
| Accession | NZ_CP063774 | ||
| Organism | Escherichia coli O25b:H4-ST131 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PLF5 |
| Locus tag | INT78_RS08835 | Protein ID | WP_000854690.1 |
| Coordinates | 1856321..1856698 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1P7N8 |
| Locus tag | INT78_RS08830 | Protein ID | WP_001305076.1 |
| Coordinates | 1855864..1856232 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| INT78_RS08790 | 1850946..1852073 | + | 1128 | Protein_1722 | hypothetical protein | - |
| INT78_RS08795 | 1852149..1852604 | + | 456 | WP_000581502.1 | hypothetical protein | - |
| INT78_RS08800 | 1852683..1852916 | + | 234 | WP_000902034.1 | DUF905 family protein | - |
| INT78_RS08805 | 1853017..1853835 | + | 819 | WP_001234620.1 | DUF945 domain-containing protein | - |
| INT78_RS08810 | 1853890..1854375 | + | 486 | WP_000849565.1 | antirestriction protein | - |
| INT78_RS08815 | 1854391..1854867 | + | 477 | WP_001186726.1 | RadC family protein | - |
| INT78_RS08820 | 1854930..1855151 | + | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
| INT78_RS08825 | 1855170..1855814 | + | 645 | WP_000094916.1 | hypothetical protein | - |
| INT78_RS08830 | 1855864..1856232 | + | 369 | WP_001305076.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| INT78_RS08835 | 1856321..1856698 | + | 378 | WP_000854690.1 | TA system toxin CbtA family protein | Toxin |
| INT78_RS08840 | 1856695..1857183 | + | 489 | WP_000761699.1 | hypothetical protein | - |
| INT78_RS08845 | 1857200..1857397 | + | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
| INT78_RS08850 | 1857482..1858327 | + | 846 | WP_001529401.1 | DUF4942 domain-containing protein | - |
| INT78_RS08855 | 1858396..1858791 | + | 396 | WP_000208384.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | - |
| INT78_RS08860 | 1858784..1859717 | + | 934 | Protein_1736 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| INT78_RS08865 | 1860149..1860304 | + | 156 | WP_000729638.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | kpsF / kpsE / kpsD / kpsU / kpsC / kpsS / kpsT / kpsM / gspM | 1811586..1881354 | 69768 | |
| - | flank | IS/Tn | - | - | 1860149..1860304 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14057.04 Da Isoelectric Point: 9.1510
>T178798 WP_000854690.1 NZ_CP063774:1856321-1856698 [Escherichia coli O25b:H4-ST131]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
Download Length: 378 bp
>T178798 NZ_CP084298:c14912-14631 [Acinetobacter baumannii]
ATGGCTATCAAACTTCGCAAATGGGACAGTGCTGAACATCTTAAAACAGAAGAAGATATGCAAGCTTACCTACAAGCCTG
TATCGATGAATCTAATGGTGATGCGGCATTCATTGCAAAAGCTTTAGGTAATATTGCTAAAGCTAAAGGAATGGCTCAAT
TATCAAGAGACACTGGTTTAGGTCGAGAAAGTCTTTATAAAGCACTTTCTGGCGATGTAAATCCAAGCTTTGATACTGTT
ATTAAAGTCGTAAAAGCACTGAATTTACGCTTAGCAATTTAA
ATGGCTATCAAACTTCGCAAATGGGACAGTGCTGAACATCTTAAAACAGAAGAAGATATGCAAGCTTACCTACAAGCCTG
TATCGATGAATCTAATGGTGATGCGGCATTCATTGCAAAAGCTTTAGGTAATATTGCTAAAGCTAAAGGAATGGCTCAAT
TATCAAGAGACACTGGTTTAGGTCGAGAAAGTCTTTATAAAGCACTTTCTGGCGATGTAAATCCAAGCTTTGATACTGTT
ATTAAAGTCGTAAAAGCACTGAATTTACGCTTAGCAATTTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13560.39 Da Isoelectric Point: 4.7830
>AT178798 WP_001305076.1 NZ_CP063774:1855864-1856232 [Escherichia coli O25b:H4-ST131]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
Download Length: 369 bp
>AT178798 NZ_CP084298:c15215-14913 [Acinetobacter baumannii]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTTACTAAGTTAAAAGACCTGCAGGCAAAAAGACGTATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAACCAGTAGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGACCTGGCTACAGGATCTATTACTGTAAGCAAGGGCAAAGGGTCGTTATTCTTTTAGCAGGCGGAGACAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTACAATTAGCACAAGATTTAGAGGAGGAGCTGTAA
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTTACTAAGTTAAAAGACCTGCAGGCAAAAAGACGTATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAACCAGTAGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGACCTGGCTACAGGATCTATTACTGTAAGCAAGGGCAAAGGGTCGTTATTCTTTTAGCAGGCGGAGACAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTACAATTAGCACAAGATTTAGAGGAGGAGCTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|