Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2601929..2602554 Replicon chromosome
Accession NZ_CP063773
Organism Pectobacterium carotovorum subsp. carotovorum PCCS1

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag IQ281_RS11640 Protein ID WP_005976087.1
Coordinates 2601929..2602132 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag IQ281_RS11645 Protein ID WP_005976089.1
Coordinates 2602186..2602554 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQ281_RS11610 2597370..2597708 + 339 WP_002208627.1 P-II family nitrogen regulator -
IQ281_RS11615 2597746..2599032 + 1287 WP_015839357.1 ammonium transporter AmtB -
IQ281_RS11620 2599185..2600048 - 864 WP_015839358.1 acyl-CoA thioesterase II -
IQ281_RS11625 2600261..2600842 + 582 WP_194429751.1 YbaY family lipoprotein -
IQ281_RS11630 2600862..2601182 - 321 WP_015839360.1 MGMT family protein -
IQ281_RS11640 2601929..2602132 - 204 WP_005976087.1 hemolysin expression modulator Hha Toxin
IQ281_RS11645 2602186..2602554 - 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
IQ281_RS11650 2603151..2603294 - 144 WP_005976091.1 type B 50S ribosomal protein L36 -
IQ281_RS11655 2603312..2603560 - 249 WP_015839361.1 type B 50S ribosomal protein L31 -
IQ281_RS11660 2603795..2606923 - 3129 WP_015839362.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T178781 WP_005976087.1 NZ_CP063773:c2602132-2601929 [Pectobacterium carotovorum subsp. carotovorum PCCS1]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T178781 NZ_CP084290:2484285-2484461 [Citrobacter werkmanii]
GTGAAGCAAAGTGAGTTCAGACGCTGGCTTGAATCTCAGGGAGTTAAAGTTACAAACGGCTCAAATCATCTGAAGTTGAG
GTATCAGGGAAGGCGTAGCGTTATGCCCAGGCATCCTGGTGATGAGATAAAAGAGGCCCTGCGAAAAGCGATCCAAAAGC
AGCTTGGCTTACAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT178781 WP_005976089.1 NZ_CP063773:c2602554-2602186 [Pectobacterium carotovorum subsp. carotovorum PCCS1]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT178781 NZ_CP084290:2484508-2484924 [Citrobacter werkmanii]
ATGCGTTATCCCGTTAATCTAATACCCGCCGTGGAAGGTGGGTTCATGGTGTCTTTTCCGGATATTCCTGAAGCATTGAC
TCAGGGAGAAACTCGCCATGATGCTTTGCAGGCTGCGCAGGCCGCATTGGTCACCGCTTTTGAATTCTATTTCGACGATA
ACGAACCGATTCCTTTGCCTTCAGCGGTTGTCGCTGGCGCTGACTATGTGGAAATACCACTGAGCGTTGCGTCTAAGGTT
CTGTTGTTAAATGCCTTCCTTGAATCGAATATTACCCAGCAGGAGTTGGCAAACAGGATCGGCAGGCCTAAGCAGGAAAT
CACCCGTTTATTCGATTTAAAGCACGCGACAAAAATTGATGCTGTGCAGATAGCTGCCCGCGCTTTAGGAAAAGAACTGT
CGGTAACGATGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References