Detailed information of TA system TA178779

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 2144296..2144956
• Replicon: chromosome
• Accession: NZ_CP063773
• Organism: Pectobacterium carotovorum subsp. carotovorum PCCS1

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: IQ281_RS09675
• Protein ID: WP_194431592.1
• Coordinates: 2144543..2144956 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: C6D8Y5
• Locus tag: IQ281_RS09670
• Protein ID: WP_012773340.1
• Coordinates: 2144296..2144562 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IQ281_RS09650	2139933..2141255	+	1323	WP_194431758.1	MHS family MFS transporter	-
IQ281_RS09655	2141332..2141940	-	609	WP_194431590.1	HD domain-containing protein	-
IQ281_RS09660	2142355..2143002	+	648	WP_012773338.1	hemolysin III family protein	-
IQ281_RS09665	2143059..2144060	-	1002	WP_194431591.1	tRNA-modifying protein YgfZ	-
IQ281_RS09670	2144296..2144562	+	267	WP_012773340.1	FAD assembly factor SdhE	Antitoxin
IQ281_RS09675	2144543..2144956	+	414	WP_194431592.1	protein YgfX	Toxin
IQ281_RS09680	2145026..2145961	+	936	WP_181829656.1	23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF	-
IQ281_RS09685	2146007..2146330	-	324	WP_180777498.1	hypothetical protein	-
IQ281_RS09690	2146359..2146877	-	519	WP_012773344.1	flavodoxin FldB	-
IQ281_RS09695	2147040..2148368	-	1329	WP_194431593.1	MHS family MFS transporter	-
IQ281_RS09700	2148680..2149579	+	900	WP_012773347.1	site-specific tyrosine recombinase XerD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16303.19 Da
• Isoelectric Point: 10.3509

>T178779 WP_194431592.1 NZ_CP063773:2144543-2144956 [Pectobacterium carotovorum subsp. carotovorum PCCS1]
VAQWQCDLRVSWRMQLLSLIVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGEIVLLSETTLNWRQQ
EWQIVKRPWLLKNGVLLSLQAVDGKDRQQLWLASDSMGDDEWRHLRQLLLQQKNWAR

Nucleotide

• Length: 414 bp

>T178779 NZ_CP084290:909008-909415 [Citrobacter werkmanii]
GTGGTCCAGTGGCAATCTGATTTACGCGTTTCATGGCGCGCGCAGTGGCTTTCGTTGCTCGTTCATGGGCTGGTCGCGGT
ATTTATTTTATTGATGCCCTGGCCTTTGAGCTACACCCCATTATGGATGGTTCTGCTCTCTCTGGTGGTGTTCGATAGCG
TACGCAGCCAACGTAGAATTAATGCCTGCCAGGGCGAGATTAGGCTGTTGATGGACGGCCGTCTGCGCTGGCAAGGGCAG
GAGTGGACTATCGTTAGCGCGCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGTTCAGATACCGGGAAACGTCA
GCATTTGTGGCTGGCGGCAGACAGTATGGATGAGGCTGAGTGGCGAGACTTACGGCGGTTAATGCTGCAACAGGCCAAGC
AGGGGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10465.94 Da
• Isoelectric Point: 6.2223

>AT178779 WP_012773340.1 NZ_CP063773:2144296-2144562 [Pectobacterium carotovorum subsp. carotovorum PCCS1]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLSDSDKRTFVRLLQSDDPDLFNWLMNHGEPKDGELKRMISLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT178779 NZ_CP084290:908761-909027 [Citrobacter werkmanii]
ATGGATATTAACAATAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGCGAGCTGGACATCTCTATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGACGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTCAGTTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7W2E501