Detailed information of TA system TA178772

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1162407..1163041
• Replicon: chromosome
• Accession: NZ_CP063773
• Organism: Pectobacterium carotovorum subsp. carotovorum PCCS1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: IQ281_RS05315
• Protein ID: WP_194431738.1
• Coordinates: 1162766..1163041 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: IQ281_RS05310
• Protein ID: WP_181830203.1
• Coordinates: 1162407..1162769 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IQ281_RS05295	1158730..1159692	-	963	WP_012772882.1	6-phosphofructokinase	-
IQ281_RS05300	1159900..1160802	-	903	WP_012772881.1	CDF family cation-efflux transporter FieF	-
IQ281_RS05305	1160846..1162033	-	1188	WP_180779137.1	sugar transporter	-
IQ281_RS05310	1162407..1162769	-	363	WP_181830203.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
IQ281_RS05315	1162766..1163041	-	276	WP_194431738.1	type II toxin-antitoxin system HicA family toxin	Toxin
IQ281_RS05320	1163277..1163801	-	525	WP_012772879.1	cell-envelope stress modulator CpxP	-
IQ281_RS05325	1163955..1164653	+	699	WP_012772878.1	envelope stress response regulator transcription factor CpxR	-
IQ281_RS05330	1164650..1166020	+	1371	WP_182100782.1	envelope stress sensor histidine kinase CpxA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (30-80)

Antitoxin

• Uncharacterised protein family HicB (61-113)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10067.68 Da
• Isoelectric Point: 11.1875

>T178772 WP_194431738.1 NZ_CP063773:c1163041-1162766 [Pectobacterium carotovorum subsp. carotovorum PCCS1]
MQGKIASLRKKQRETLSQIFKTPVLSGVKWSNVESLITALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGALVNL
REWLESIGVKL

Nucleotide

• Length: 276 bp

>T178772 NZ_CP084283:800394-800594 [Caballeronia zhejiangensis]
ATGGATTCATCGCGCTTGATACGAATGCTGCTGGATGACGGGTGGCACTTGGACCGAATTGTCGGCAGTCACCATCATTT
CAAACGTCGGGGAAATATGAGCTTGGTCACGGTGCCTCATCCCCGAAAAGATCTTTCCATTGGAACGGTAAGAAGCGTCC
TCAAGACGGCCGGGTTGCTCAACCGGCTGTACTCTTCATAA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13577.41 Da
• Isoelectric Point: 4.4981

>AT178772 WP_181830203.1 NZ_CP063773:c1162769-1162407 [Pectobacterium carotovorum subsp. carotovorum PCCS1]
MTKALNTPNTMVVSGQPAIISYVPEIGMFRGKFIGLSGYCDFVADSINGLRNEGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTIAAAERQISVNTFIVETLNERMKQA

Nucleotide

• Length: 363 bp

>AT178772 NZ_CP084283:800608-801009 [Caballeronia zhejiangensis]
GTGGAATTCCCAGTCGCCATTCACAAAGACCCGGACAGTTGCTACGGCGTTACCGTGCCTGACATTCCCGGCGTTTTTTC
TGCGGGAGAGACGGTCGACGAGGCAATTAAAAATACGAAGGAGGCAATCTACAGCCACGTCTCGATTCTTATAGAGGACG
GTTTGGACGTTTCGCTGGTGCCTTCCCCGATTGAAGATCTGATGCCGAACCCCGACTTCGCCACGGCAATCTGGGCCTAC
GTCGAAGTCGATCTCTCGAAGCTCGACTCGCGTCCCGAGCGCATCAACATCAGCCTGCCGCGATTCGTGCTGCGCAAGAT
CGACAGCTACGTCGAGGCGCGCCACGAAACCCGCAGCGGCTTTCTGGCGCGGGTCGCGCTCGAAGCGATCGCGAACGGCT
GA