Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 2207254..2207801 Replicon chromosome
Accession NZ_CP063772
Organism Lysobacter sp. H21R4

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag INQ40_RS10060 Protein ID WP_194340322.1
Coordinates 2207254..2207556 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag INQ40_RS10065 Protein ID WP_194340323.1
Coordinates 2207544..2207801 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INQ40_RS10050 2203479..2203886 - 408 Protein_1955 M23 family metallopeptidase -
INQ40_RS10055 2204408..2207002 - 2595 WP_194340321.1 type VI secretion system tip protein VgrG -
INQ40_RS10060 2207254..2207556 - 303 WP_194340322.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
INQ40_RS10065 2207544..2207801 - 258 WP_194340323.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
INQ40_RS10070 2207922..2208275 + 354 WP_194340324.1 hypothetical protein -
INQ40_RS10075 2208236..2208796 + 561 WP_194340325.1 hypothetical protein -
INQ40_RS10080 2209029..2209526 + 498 WP_194340326.1 pilin -
INQ40_RS10085 2209691..2209987 + 297 WP_194340327.1 hypothetical protein -
INQ40_RS10090 2210134..2210448 + 315 WP_194340328.1 type II toxin-antitoxin system RelE/ParE family toxin -
INQ40_RS10095 2210451..2210741 + 291 WP_194340329.1 transcriptional regulator -
INQ40_RS10100 2210984..2211916 + 933 Protein_1965 Fic family protein -
INQ40_RS10105 2211975..2212118 + 144 Protein_1966 XRE family transcriptional regulator -
INQ40_RS10110 2212236..2212373 - 138 Protein_1967 addiction module antidote protein, HigA family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2196233..2228294 32061


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11247.82 Da        Isoelectric Point: 5.6268

>T178769 WP_194340322.1 NZ_CP063772:c2207556-2207254 [Lysobacter sp. H21R4]
MAEIVWTEPALGDLDAIADYIALEDPVAASELVKRVLAHGEQLADHPESGSRPAELGRSRYRQVVDPPCRVFHRYDGQTV
FVLYVMRTERLLRKGQLTSV

Download         Length: 303 bp

>T178769 NZ_CP084277:c130116-129817 [Caballeronia grimmiae]
GTGAAGTCGTTTGTATTATCGCCAGCGGCGGAGGTCGATCTCGACGAGATCTGGGACTATTCGATCGAAAATTGGGGCGA
ACGTCAGGCAGAGCGATACATTCGGATGATCCAGGACACGATCATAGGGCTCGCGGATGGCACACAGTTGAGCCACTCTG
CGGAGCACGTGCGACCGAATTATCGGAAAGTCTTGGTCGGATCGCATGTACTCTTCTTCAAGGAAGACCAGCAAGTCGTC
GACGTGATTCGAATTCTTCATCAGCGAATGGATTCTTCGTTTCACTTGAACGAGCACTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9683.28 Da        Isoelectric Point: 10.4483

>AT178769 WP_194340323.1 NZ_CP063772:c2207801-2207544 [Lysobacter sp. H21R4]
MRTELVTTLKRQATELLSDIARDKEPILITQHGLPSAYLVDVESFQLMQQRMAVLEGIARGEQAIAESRVVTHAQARKRL
ARWLK

Download         Length: 258 bp

>AT178769 NZ_CP084277:c130355-130113 [Caballeronia grimmiae]
ATGGGCAAAAACACATCGGTGTCGTTGGGCGATCACTTCGCTGATTTCGTTGAGGATCGCGTCCGCGGGGGCCGCTACAA
CACCGCCAGCGACGTGGTTCGAGCGGGCCTGCGTCTGCTCGAGGAGCACGAAGCGAGGCTGGACGTCTTGCGCGCCGAGT
TGGAGAAAGGCGAACGTTCCGGGGAATCGAGACCGTTCGATTTCGATGCGTTTCTCACTCGAAAACGCAAGTTGGCCACG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References