178768

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 8875..9460 Replicon plasmid unnamed2
Accession NZ_CP063771
Organism Acinetobacter sp. Ac-14

Toxin (Protein)


Gene name brnT Uniprot ID A0A158LPL9
Locus tag IOD65_RS19510 Protein ID WP_002124950.1
Coordinates 9173..9460 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID A0A062GCE4
Locus tag IOD65_RS19505 Protein ID WP_005065064.1
Coordinates 8875..9186 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD65_RS19470 4188..5117 + 930 WP_005065049.1 replication initiation protein RepM -
IOD65_RS19475 5196..5726 + 531 WP_005065050.1 plasmid replication DNA-binding protein -
IOD65_RS19480 6076..6393 + 318 WP_005065053.1 hypothetical protein -
IOD65_RS19485 6914..7258 + 345 WP_005065055.1 type II toxin-antitoxin system RelE/ParE family toxin -
IOD65_RS19490 7263..7565 + 303 WP_005065057.1 XRE family transcriptional regulator -
IOD65_RS19495 7657..8058 + 402 WP_005065059.1 hypothetical protein -
IOD65_RS19500 8110..8784 + 675 WP_005065062.1 HEPN domain-containing protein -
IOD65_RS19505 8875..9186 - 312 WP_005065064.1 BrnA antitoxin family protein Antitoxin
IOD65_RS19510 9173..9460 - 288 WP_002124950.1 BrnT family toxin Toxin
IOD65_RS19515 9973..11460 + 1488 WP_005065066.1 SulP family inorganic anion transporter -
IOD65_RS19520 11473..12324 + 852 WP_005065068.1 universal stress protein -
IOD65_RS19525 12595..13479 - 885 WP_005065070.1 MobA/MobL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..17334 17334


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11173.58 Da        Isoelectric Point: 4.9093

>T178768 WP_002124950.1 NZ_CP063771:c9460-9173 [Acinetobacter sp. Ac-14]
MELYFEWDEAKNQKNQKKHDVSFETASLVFEDPLRISIQDRHTNGEERWQTIGMVKGVLMLLVAHTIIDDDDCEIIRIIS
ARQVTKAERNQYEHG

Download         Length: 288 bp

>T178768 NZ_CP084271:c2043747-2043547 [Caballeronia grimmiae]
ATGGATTCCTCGCGCTTGATACGAATGCTTCTGGATGACGGCTGGCACCTGGTGCGCATCAAAGGCAGTCATCACCACTT
CAAACACGGAACCCGGCAAGGCCGCTTGACTGTGGTTCATCCGAAGAAAGATCTGCCTGTCGGGACCGTCAGAGCGGTTC
TGAAAGGCGCCGGATTGCTGAACCGGCTGTACTCGTCGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 12070.80 Da        Isoelectric Point: 9.4651

>AT178768 WP_005065064.1 NZ_CP063771:c9186-8875 [Acinetobacter sp. Ac-14]
MSMVRYTRKELNEKFSDKQDAEIKRLLAKGTVPDEQLDLSDIPEITDWSHAVRHGQFYRPVKQQTSVRLDADVLAWLKAQ
GKGYQTRMNKILREAMLEDLKNH

Download         Length: 312 bp

>AT178768 NZ_CP084271:c2043532-2043131 [Caballeronia grimmiae]
ATGGAATTCGCCATCGCCATTCATAAAGAGCCGGAAAGCTGTTACGGCGTCATCGTGCCGAACGTGCCTGGTGTCTTCTC
CGCCGGAGATACGATCGATGAAGCGCTTCGCAACGCGAGGGAAGCGATCGTTGCTCATGTGCAGACGATCATCGAGGAAG
GGGAAAAGGTGGAAATCAACTCGACCAGCATCGAGGAACTGATTACCGACCCCGACTACGAAGGCGCCATCTGGGCCTTC
GTCGAAGTCGATCTCTCGAAGCTCGACTCGAAGCCCGAGCGCATCAACATCAGCTTGCCGCGCTTCGTCCTGCACAAGAT
CGACAGTTACGTCGAAGCCCGGCACGAGACGCGCAGCGGCTTTCTCGCGCGTGCCGCGCTGGAAGCGATCGCGCACGGCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A158LPL9

Antitoxin

Source ID Structure
AlphaFold DB A0A062GCE4

References