Detailed information of TA system TA178763

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2815111..2815790
• Replicon: chromosome
• Accession: NZ_CP063769
• Organism: Acinetobacter sp. Ac-14

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: IOD65_RS13450
• Protein ID: WP_000838146.1
• Coordinates: 2815608..2815790 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: IOD65_RS13445
• Protein ID: WP_000966688.1
• Coordinates: 2815111..2815515 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IOD65_RS13430	2811201..2813936	-	2736	Protein_2624	tape measure protein	-
IOD65_RS13435	2814067..2814330	-	264	WP_001275792.1	hypothetical protein	-
IOD65_RS13440	2814332..2815012	-	681	WP_000721572.1	hypothetical protein	-
IOD65_RS13445	2815111..2815515	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
IOD65_RS13450	2815608..2815790	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
IOD65_RS13455	2816116..2816631	-	516	WP_017399365.1	hypothetical protein	-
IOD65_RS13460	2816701..2817618	-	918	WP_194156748.1	hypothetical protein	-
IOD65_RS13465	2817671..2818999	-	1329	WP_194156749.1	hypothetical protein	-
IOD65_RS13470	2818999..2819352	-	354	WP_031977946.1	hypothetical protein	-
IOD65_RS13475	2819449..2819970	-	522	WP_000749906.1	SH3 domain-containing protein	-
IOD65_RS13480	2820079..2820297	-	219	WP_031977943.1	hypothetical protein	-
IOD65_RS13485	2820299..2820742	-	444	WP_000157654.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2791997..2849629	57632

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T178763 WP_000838146.1 NZ_CP063769:c2815790-2815608 [Acinetobacter sp. Ac-14]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T178763 NZ_CP084252:c446307-446092 [Caballeronia sp. Sq4a]
ATTGAAGAAGACAATCCGGCCGCCGCAGACTTCGTATTCGAAGCTCTCATCGCGGCGGCCGCTTCTTTGCCCGATCACCC
CTACGTCTACCGCGAAGGCCGCAAGCCAAACACCCGGGAGATGGTCGTGATGCCGAACTACATCATTGTGTATCGCGTGA
AGCGCGATCGTATCCAGATCGTGAACGTGCTTCACGCGCGGCGTCGTTACCCCTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT178763 WP_000966688.1 NZ_CP063769:c2815515-2815111 [Acinetobacter sp. Ac-14]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT178763 NZ_CP084252:c446549-446355 [Caballeronia sp. Sq4a]
ATGGGAAATATTTGGACCGAACCGGCAGTGAGCGGGCACGACACGAAGGAAGAAGCCGAAGCCTACGACGATTGGTTCCG
AAAGGAAGTCCAACTCGCGCTCGATGAGAAAGGCGAAGACATTCCGCACGATCAGGTCGTCGCGGAGATGCGCGCGCACA
TCGAGGCGAAACGACGGGCACGCAATGGTCGCTGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6