Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2815111..2815790 Replicon chromosome
Accession NZ_CP063769
Organism Acinetobacter sp. Ac-14

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag IOD65_RS13450 Protein ID WP_000838146.1
Coordinates 2815608..2815790 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag IOD65_RS13445 Protein ID WP_000966688.1
Coordinates 2815111..2815515 (-) Length 135 a.a.

Genomic Context

IOD65_RS13430IOD65_RS13435IOD65_RS13440IOD65_RS13445IOD65_RS13450IOD65_RS13455IOD65_RS13460IOD65_RS13465IOD65_RS13470IOD65_RS13475IOD65_RS13480IOD65_RS13485
Location: 2811201..2813936 (2736 bp)
Type: Others
Protein ID: Protein_2624
Location: 2814067..2814330 (264 bp)
Type: Others
Protein ID: WP_001275792.1
Location: 2814332..2815012 (681 bp)
Type: Others
Protein ID: WP_000721572.1
Location: 2815111..2815515 (405 bp)
Type: Antitoxin
Protein ID: WP_000966688.1
Location: 2815608..2815790 (183 bp)
Type: Toxin
Protein ID: WP_000838146.1
Location: 2816116..2816631 (516 bp)
Type: Others
Protein ID: WP_017399365.1
Location: 2816701..2817618 (918 bp)
Type: Others
Protein ID: WP_194156748.1
Location: 2817671..2818999 (1329 bp)
Type: Others
Protein ID: WP_194156749.1
Location: 2818999..2819352 (354 bp)
Type: Others
Protein ID: WP_031977946.1
Location: 2819449..2819970 (522 bp)
Type: Others
Protein ID: WP_000749906.1
Location: 2820079..2820297 (219 bp)
Type: Others
Protein ID: WP_031977943.1
Location: 2820299..2820742 (444 bp)
Type: Others
Protein ID: WP_000157654.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IOD65_RS134302811201..2813936-2736Protein_2624tape measure protein-
IOD65_RS134352814067..2814330-264WP_001275792.1hypothetical protein-
IOD65_RS134402814332..2815012-681WP_000721572.1hypothetical protein-
IOD65_RS134452815111..2815515-405WP_000966688.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
IOD65_RS134502815608..2815790-183WP_000838146.1type II toxin-antitoxin system HicA family toxinToxin
IOD65_RS134552816116..2816631-516WP_017399365.1hypothetical protein-
IOD65_RS134602816701..2817618-918WP_194156748.1hypothetical protein-
IOD65_RS134652817671..2818999-1329WP_194156749.1hypothetical protein-
IOD65_RS134702818999..2819352-354WP_031977946.1hypothetical protein-
IOD65_RS134752819449..2819970-522WP_000749906.1SH3 domain-containing protein-
IOD65_RS134802820079..2820297-219WP_031977943.1hypothetical protein-
IOD65_RS134852820299..2820742-444WP_000157654.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--2791997..284962957632


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T178763 WP_000838146.1 NZ_CP063769:c2815790-2815608 [Acinetobacter sp. Ac-14]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T178763 NZ_CP084252:c446307-446092 [Caballeronia sp. Sq4a]
ATTGAAGAAGACAATCCGGCCGCCGCAGACTTCGTATTCGAAGCTCTCATCGCGGCGGCCGCTTCTTTGCCCGATCACCC
CTACGTCTACCGCGAAGGCCGCAAGCCAAACACCCGGGAGATGGTCGTGATGCCGAACTACATCATTGTGTATCGCGTGA
AGCGCGATCGTATCCAGATCGTGAACGTGCTTCACGCGCGGCGTCGTTACCCCTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT178763 WP_000966688.1 NZ_CP063769:c2815515-2815111 [Acinetobacter sp. Ac-14]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT178763 NZ_CP084252:c446549-446355 [Caballeronia sp. Sq4a]
ATGGGAAATATTTGGACCGAACCGGCAGTGAGCGGGCACGACACGAAGGAAGAAGCCGAAGCCTACGACGATTGGTTCCG
AAAGGAAGTCCAACTCGCGCTCGATGAGAAAGGCGAAGACATTCCGCACGATCAGGTCGTCGCGGAGATGCGCGCGCACA
TCGAGGCGAAACGACGGGCACGCAATGGTCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBS3TWT7

Antitoxin

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Source
ID
Structure
AlphaFold DBN9L2H6

References