Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4999089..4999605 Replicon chromosome
Accession NZ_CP063759
Organism Klebsiella pneumoniae strain FRPDR

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag IM727_RS24835 Protein ID WP_002886902.1
Coordinates 4999089..4999373 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag IM727_RS24840 Protein ID WP_002886901.1
Coordinates 4999363..4999605 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM727_RS24810 4994573..4994881 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
IM727_RS24815 4994966..4995139 + 174 WP_002886906.1 hypothetical protein -
IM727_RS24820 4995142..4995885 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
IM727_RS24825 4996242..4998380 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
IM727_RS24830 4998621..4999085 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IM727_RS24835 4999089..4999373 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IM727_RS24840 4999363..4999605 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IM727_RS24845 4999683..5001593 - 1911 WP_004152270.1 BglG family transcription antiterminator -
IM727_RS24850 5001616..5002770 - 1155 WP_002886900.1 lactonase family protein -
IM727_RS24855 5002836..5003576 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T178746 WP_002886902.1 NZ_CP063759:c4999373-4999089 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T178746 NZ_CP084235:1859668-1859856 [Staphylococcus haemolyticus]
ATGAGTTTGCATTTAACTATATTGTTATGGCTTGGTATCATTTTTGTAATAGCAGCCTCAATTATATTGGGCTTATTACT
TAAATCTAAAAAAGAAGAACGTAAAGAATCCTATTTAGGTTTTACCGTAATATTTTATATTTTTGGATTTGCTTTACTCA
TCTACGTATTCATATTTGGTATATTATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT178746 WP_002886901.1 NZ_CP063759:c4999605-4999363 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT178746 NZ_CP084235:1859388-1859645 [Staphylococcus haemolyticus]
ATGAATAATAATAAAATTTTTTGGATAAATATTTTTATTACGCTATTATTTTTGGGTTTCAATATCATTGTTACTTACAA
TGCAGAATTAGATGATTTCTTCTGGCTAATTCCAGGACTTACAATTAGTGGTATCACAATTGTACTAAGCTTAAGTACTG
CGCTCATTTGCAAGAACCTGGTTAGCGAAGTTATTTTTCTAATCAATATTGCTATGCTTTTATACTACATTTATCCTATA
GTATATACATTCTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References