Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2823865..2825453 Replicon chromosome
Accession NZ_CP063759
Organism Klebsiella pneumoniae strain FRPDR

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag IM727_RS14125 Protein ID WP_004199851.1
Coordinates 2823865..2825187 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag IM727_RS14130 Protein ID WP_002904790.1
Coordinates 2825187..2825453 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM727_RS14110 2818930..2821431 + 2502 WP_004199853.1 fimbrial biogenesis outer membrane usher protein -
IM727_RS14115 2821419..2822423 + 1005 WP_004199852.1 type 1 fimbrial protein -
IM727_RS14120 2822556..2823848 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
IM727_RS14125 2823865..2825187 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
IM727_RS14130 2825187..2825453 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
IM727_RS14135 2825719..2826045 - 327 WP_002904788.1 hydroxyisourate hydrolase -
IM727_RS14140 2826042..2826542 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
IM727_RS14145 2826520..2827899 - 1380 WP_004199850.1 purine permease -
IM727_RS14150 2828245..2829399 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
IM727_RS14155 2829380..2830303 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T178743 WP_004199851.1 NZ_CP063759:c2825187-2823865 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T178743 NZ_CP084235:809675-809881 [Staphylococcus haemolyticus]
ATGAACTTTAGTGAAATTAGAATTAGTGAATTAAATACTGAAGAGCAAGCTAATTCGCTCCAACATAGACTTGAGAAGAT
GATAGGTGTAGATGAAGTAATTGTAGAACTAAATGACCAATTAGTTAAAATTTCTTTTGAAACACCAACGAATTTAAATA
GTATTGAAAAAGAAATTTATGATGATGGTTATAAGGTATTAGGTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT178743 WP_002904790.1 NZ_CP063759:c2825453-2825187 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT178743 NZ_CP084235:809370-809663 [Staphylococcus haemolyticus]
TTGAATAATCATGAAAATGCACATCATTCCGAGCAAATTAAAATGAATTTAAAATCAAGACTAAATCGTATTGAAGGGCA
AGTTAGAGCGATTAATCGCATGATTGAAGAAGATGTATACTGTGATGACGTGCTAACTCAAATTAGAGCTACAAGATCTG
CATTAAATAGTGTGGCCACTAAGTTGCTAGATCATCATATGAAAAGCTGTATCATGGATAAAGTGAATAACGGCGCTCAA
GAAGAAGCGATGGAAGAATTGTTAGTGACATTTCAAAAATTAATGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References