178729

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 306840..307362 Replicon plasmid pKP19-3023-374k
Accession NZ_CP063748
Organism Klebsiella pneumoniae strain KP19-3023

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag IMY55_RS27650 Protein ID WP_004181778.1
Coordinates 307078..307362 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag IMY55_RS27645 Protein ID WP_004181777.1
Coordinates 306840..307088 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMY55_RS27625 302010..302867 - 858 WP_064371183.1 hypothetical protein -
IMY55_RS27630 302927..303280 - 354 WP_042927270.1 hypothetical protein -
IMY55_RS27635 303416..304420 - 1005 WP_064371184.1 hypothetical protein -
IMY55_RS27640 304749..306548 - 1800 WP_064371185.1 ATP-dependent helicase -
IMY55_RS27645 306840..307088 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IMY55_RS27650 307078..307362 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IMY55_RS27655 307383..307775 - 393 WP_052626761.1 type II toxin-antitoxin system PrlF family antitoxin -
IMY55_RS27660 307869..308051 + 183 WP_044349315.1 type II toxin-antitoxin system HicA family toxin -
IMY55_RS27665 308095..308526 + 432 WP_044349313.1 hypothetical protein -
IMY55_RS27670 308531..308818 + 288 WP_044349311.1 helix-turn-helix transcriptional regulator -
IMY55_RS27675 309617..309895 + 279 WP_044349308.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / aac(3)-IId / mph(A) / sul1 / blaNDM-1 / qacE / qnrB6 / aadA16 / dfrA27 / ARR-3 katA 1..374513 374513


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T178729 WP_004181778.1 NZ_CP063748:307078-307362 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T178729 NZ_CP084222:c1246747-1246454 [Arsenophonus apicola]
ATGTCACTACAATTTGAATGGGATCCTGAAAAATCAGCATCAAATTTAAAAAAACATGGGATTCGATTTGAAGAAGCTGC
ACAGGTTTTCAATGATCCTATGCATTTATCTCATCAGGATCGTTTCGAAAATGGAGAATTGCGTTGGCAAACCATTGGGC
AAGTTGGAGGTTGTATTATTGTTTTTGTCGCACACACGATAAATTTTGAAAATTCAGTAGAAATTATTCGAATAATCAGC
GCCCGAAGAGCGACGCGCGCAGAGAGAAAACATTATGAAAAAAGTTACTATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT178729 WP_004181777.1 NZ_CP063748:306840-307088 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT178729 NZ_CP084222:c1246473-1246168 [Arsenophonus apicola]
ATGAAAAAAGTTACTATTAAACAAAATGCCTTACCAACATTAACTGATAAACGCAAAGCAGAGTTGAAAGTACTGGCTGG
TATGCCGGAAAGTGAAATAAATTTTAGTGACATCCCACCAATGGATGAAGTGACATGGCAAAATGCCCATCGGGGTAATT
TTTATCGTCCTATTAAACAGCATGCTTCTGTCCGCATTGATGCCGATGTTTTGGCGTGGCTCAGAGGATCAGGGAAAGGC
TATCAGACGCGTTTAAACGCAATTTTAAGAGCGGCAATGCTCAAAGACTTAAATAATAAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References