Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4761688..4762204 Replicon chromosome
Accession NZ_CP063747
Organism Klebsiella pneumoniae strain KP19-3023

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag IMY55_RS23375 Protein ID WP_002886902.1
Coordinates 4761688..4761972 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag IMY55_RS23380 Protein ID WP_002886901.1
Coordinates 4761962..4762204 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMY55_RS23350 4757172..4757480 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
IMY55_RS23355 4757565..4757738 + 174 WP_002886906.1 hypothetical protein -
IMY55_RS23360 4757741..4758484 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
IMY55_RS23365 4758841..4760979 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
IMY55_RS23370 4761220..4761684 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IMY55_RS23375 4761688..4761972 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IMY55_RS23380 4761962..4762204 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IMY55_RS23385 4762282..4764192 - 1911 WP_004152270.1 BglG family transcription antiterminator -
IMY55_RS23390 4764215..4765369 - 1155 WP_002886900.1 lactonase family protein -
IMY55_RS23395 4765435..4766175 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T178725 WP_002886902.1 NZ_CP063747:c4761972-4761688 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T178725 NZ_CP084216:c4406526-4406215 [Salmonella sp. JXY0409-18]
ATGCAATTCATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGCAGTGGCGTACGAATTATCTATTTTCATCGTAGTCAACGGTATGAGGTTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT178725 WP_002886901.1 NZ_CP063747:c4762204-4761962 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT178725 NZ_CP084216:c4406214-4405924 [Salmonella sp. JXY0409-18]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References