Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4046906..4047525 Replicon chromosome
Accession NZ_CP063747
Organism Klebsiella pneumoniae strain KP19-3023

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag IMY55_RS19960 Protein ID WP_002892050.1
Coordinates 4047307..4047525 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag IMY55_RS19955 Protein ID WP_002892066.1
Coordinates 4046906..4047280 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMY55_RS19945 4042058..4043251 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IMY55_RS19950 4043274..4046420 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
IMY55_RS19955 4046906..4047280 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
IMY55_RS19960 4047307..4047525 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
IMY55_RS19965 4047684..4048250 + 567 WP_002892030.1 maltose O-acetyltransferase -
IMY55_RS19970 4048222..4048362 - 141 WP_004147370.1 hypothetical protein -
IMY55_RS19975 4048383..4048853 + 471 WP_002892026.1 YlaC family protein -
IMY55_RS19980 4048828..4050279 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
IMY55_RS19985 4050380..4051078 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
IMY55_RS19990 4051075..4051215 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
IMY55_RS19995 4051215..4051478 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T178723 WP_002892050.1 NZ_CP063747:4047307-4047525 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T178723 NZ_CP084216:c3998838-3998554 [Salmonella sp. JXY0409-18]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATTGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT178723 WP_002892066.1 NZ_CP063747:4046906-4047280 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT178723 NZ_CP084216:c3999070-3998828 [Salmonella sp. JXY0409-18]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAGGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAGGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References