Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 870794..871451 Replicon chromosome
Accession NZ_CP063747
Organism Klebsiella pneumoniae strain KP19-3023

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag IMY55_RS04410 Protein ID WP_002916310.1
Coordinates 871041..871451 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag IMY55_RS04405 Protein ID WP_002916312.1
Coordinates 870794..871060 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMY55_RS04380 865950..867383 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
IMY55_RS04385 867502..868230 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
IMY55_RS04390 868280..868591 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
IMY55_RS04395 868755..869414 + 660 WP_002916317.1 hemolysin III family protein -
IMY55_RS04400 869565..870548 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
IMY55_RS04405 870794..871060 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
IMY55_RS04410 871041..871451 + 411 WP_002916310.1 protein YgfX Toxin
IMY55_RS04415 871458..871979 - 522 WP_002916308.1 flavodoxin FldB -
IMY55_RS04420 872080..872976 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
IMY55_RS04425 872999..873712 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IMY55_RS04430 873718..875451 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T178713 WP_002916310.1 NZ_CP063747:871041-871451 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T178713 NZ_CP084213:c8790-8491 [Pseudomonas amygdali]
ATGAAAGAACAATTTTACGACTACGACCCCGCTGATGCGCTGACCGATGCTGAGTCCATCGCGGTATTCATGGAGGACGC
ATTCGAAACAGGCGATGCGGCCTATATCGCAAAATGCCTGGGTGTCGTGGCCCGCGCCAAAGGGATGACCGCCCTTGCCA
ATGAATCTGGCCTTTCCCGCGAACACCTTTACCGATCGTTCTCGGACAAAGGCAACCCGACCTTGAAAACCCTGCTGGCC
GTGATGCGTGCCGTTGGCCTGGACCTTACAACTCGCAAGCACGTTGAACCGGCACACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT178713 WP_002916312.1 NZ_CP063747:870794-871060 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT178713 NZ_CP084213:c9089-8787 [Pseudomonas amygdali]
ATGAAGACAATTAAACAAACCGCCACGTACAGGAACTGGGAACGCAAGCTGCGAGACAAGCAGGCCAAAGCCATCATCGC
TGCGCGAGTCTTCCGCGTTGCACATGGTCTGCTTGGAGACGTTCAACCAGTGGGCCAAGGGATCAGCGAACTGCGTATCC
ACCACGGCCCCGGCTACCGCGTGTATTTCCAGCAGCGCGGTAACCAGCTGGTCCTGTTGCTGTGTGGTGGGGACAAGAGC
AGCCAAGCGCGGGATATCGAAACCGCCAAGTCCTTGGCCAGCCAGTGGAGTGACGATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References