Detailed information of TA system TA178693

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): lsoAB/RnlA-RnlB
• Location: 61412..62829
• Replicon: plasmid pSEN-DRC
• Accession: NZ_CP063706
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain CP255

Toxin (Protein)

• Gene name: lsoA
• Uniprot ID: O82881
• Locus tag: IRO95_RS23360
• Protein ID: WP_000068433.1
• Coordinates: 61412..62452 (+)
• Length: 347 a.a.

Antitoxin (Protein)

• Gene name: lsoB
• Uniprot ID: Q799K6
• Locus tag: IRO95_RS23365
• Protein ID: WP_000710826.1
• Coordinates: 62449..62829 (+)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IRO95_RS23350	56729..57286	-	558	WP_001235713.1	recombinase family protein	-
IRO95_RS23355	57450..60455	+	3006	WP_001143760.1	Tn3-like element Tn3 family transposase	-
IRO95_RS23360	61412..62452	+	1041	WP_000068433.1	type II toxin-antitoxin system mRNA endoribonuclease LsoA	Toxin
IRO95_RS23365	62449..62829	+	381	WP_000710826.1	type II toxin-antitoxin system antitoxin LsoB	Antitoxin
IRO95_RS23370	63064..63387	-	324	WP_000166966.1	hypothetical protein	-
IRO95_RS23375	63672..63821	+	150	WP_001677812.1	Rop family plasmid primer RNA-binding protein	-
IRO95_RS23380	63960..64820	-	861	WP_000027057.1	class A broad-spectrum beta-lactamase TEM-1	-
IRO95_RS23385	65003..65335	-	333	Protein_82	recombinase family protein	-
IRO95_RS23390	65401..66105	+	705	WP_001067848.1	IS6-like element IS26 family transposase	-
IRO95_RS23395	66245..67060	+	816	WP_000018326.1	aminoglycoside O-phosphotransferase APH(3')-Ia	-
IRO95_RS23400	67214..67405	-	192	WP_194199107.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..95694	95694

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-79)

Sequences

Toxin

Protein

• Length: 347 a.a.
• Molecular weight: 44494.43 Da
• Isoelectric Point: 13.3391

>T178693 WP_000068433.1 NZ_CP063706:61412-62452 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 1041 bp

>T178693 NZ_CP084209:2233841-2234128 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 16296.13 Da
• Isoelectric Point: 12.9004

>AT178693 WP_000710826.1 NZ_CP063706:62449-62829 [Salmonella enterica subsp. enterica serovar Enteritidis]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 381 bp

>AT178693 NZ_CP084209:2233602-2233841 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Structures

Toxin

• PDB: 5HY3

Antitoxin

• AlphaFold DB: A0A5Y2PL65