Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 1285686..1286239 Replicon chromosome
Accession NZ_CP063683
Organism Vibrio splendidus strain ED144

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag IM698_RS21260 Protein ID WP_260811324.1
Coordinates 1285946..1286239 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag IM698_RS21255 Protein ID WP_065206367.1
Coordinates 1285686..1285946 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM698_RS21225 (IM698_21190) 1281077..1281286 + 210 WP_114635717.1 hypothetical protein -
IM698_RS21230 1281279..1281395 + 117 Protein_1088 prepilin-type N-terminal cleavage/methylation domain-containing protein -
IM698_RS21235 (IM698_21200) 1282294..1284090 + 1797 WP_260811321.1 hypothetical protein -
IM698_RS21240 (IM698_21205) 1284348..1284779 + 432 WP_260811322.1 TetR/AcrR family transcriptional regulator -
IM698_RS21245 (IM698_21210) 1284802..1285131 - 330 WP_260811323.1 hypothetical protein -
IM698_RS21250 (IM698_21215) 1285135..1285443 - 309 WP_065206368.1 hypothetical protein -
IM698_RS21255 (IM698_21220) 1285686..1285946 + 261 WP_065206367.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IM698_RS21260 (IM698_21225) 1285946..1286239 + 294 WP_260811324.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IM698_RS21265 (IM698_21230) 1286792..1287310 + 519 WP_260811325.1 hypothetical protein -
IM698_RS21270 (IM698_21235) 1287347..1287703 + 357 WP_260811326.1 MerR family transcriptional regulator -
IM698_RS21275 (IM698_21240) 1287764..1288144 + 381 WP_260811327.1 carboxymuconolactone decarboxylase family protein -
IM698_RS21280 (IM698_21245) 1288257..1289138 - 882 WP_054546206.1 AEC family transporter -
IM698_RS21285 (IM698_21250) 1289426..1290760 - 1335 WP_260811328.1 guanine deaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11454.25 Da        Isoelectric Point: 10.0676

>T178689 WP_260811324.1 NZ_CP063683:1285946-1286239 [Vibrio splendidus]
MTHYKLSSAAQSDLIEVRRYTLERWGQTQWTAYFSELKQSMELLASNKLLGIAVSELRQDYFRFPLKHHVIYYTRKQEHI
IIAAILGKHMSPAKHFS

Download         Length: 294 bp

>T178689 NZ_CP084209:1790537-1790788 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9609.99 Da        Isoelectric Point: 4.3867

>AT178689 WP_065206367.1 NZ_CP063683:1285686-1285946 [Vibrio splendidus]
MQSLTANTAKTKFGDLLMKVQREPIQINKNGSPVAVMMSCEEYEQLEAMKLMFVKSRFEQAEADALSGNLVDGNDFMNAL
DQGKFD

Download         Length: 261 bp

>AT178689 NZ_CP084209:1790785-1791039 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References