Detailed information of TA system TA178688

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 909739..910312
• Replicon: chromosome
• Accession: NZ_CP063683
• Organism: Vibrio splendidus strain ED144

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q5DZS7
• Locus tag: IM698_RS19585
• Protein ID: WP_011263487.1
• Coordinates: 909739..910053 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B6ERG3
• Locus tag: IM698_RS19590
• Protein ID: WP_012551865.1
• Coordinates: 910058..910312 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IM698_RS19560 (IM698_19530)	904879..905400	+	522	WP_260812079.1	gluconokinase	-
IM698_RS19565 (IM698_19535)	905397..907193	+	1797	WP_260812080.1	phosphogluconate dehydratase	-
IM698_RS19570 (IM698_19540)	907267..908274	-	1008	WP_248398900.1	LacI family DNA-binding transcriptional regulator	-
IM698_RS19575 (IM698_19545)	908419..909120	-	702	WP_248398902.1	lipoate--protein ligase	-
IM698_RS19580 (IM698_19550)	909321..909590	+	270	WP_248398904.1	type II toxin-antitoxin system RelE/ParE family toxin	-
IM698_RS19585 (IM698_19555)	909739..910053	-	315	WP_011263487.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IM698_RS19590 (IM698_19560)	910058..910312	-	255	WP_012551865.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IM698_RS19595 (IM698_19565)	910395..910486	-	92	Protein_761	DUF3265 domain-containing protein	-
IM698_RS19600 (IM698_19570)	910511..910987	-	477	WP_248398906.1	GNAT family N-acetyltransferase	-
IM698_RS19605 (IM698_19575)	911143..911862	-	720	WP_248398908.1	hypothetical protein	-
IM698_RS19610 (IM698_19580)	912071..912409	+	339	WP_248398912.1	hypothetical protein	-
IM698_RS19615 (IM698_19585)	912771..913160	+	390	WP_260812081.1	phage integrase N-terminal SAM-like domain-containing protein	-
IM698_RS19620 (IM698_19590)	913269..914168	+	900	WP_260812082.1	homocysteine S-methyltransferase family protein	-
IM698_RS19625 (IM698_19595)	914283..915293	+	1011	WP_260812083.1	Gfo/Idh/MocA family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	909321..912409	3088

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-65)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12204.10 Da
• Isoelectric Point: 4.5467

>T178688 WP_011263487.1 NZ_CP063683:c910053-909739 [Vibrio splendidus]
MAVINWTESALLDLDEIAEYIAINNILAAKALVQSVFHRVERLEDFPLSGRSVPELPHLDYREIVLPPCRIFYKVTNDDI
VYILYVMREERELRQFVLNDRGLQ

Nucleotide

• Length: 315 bp

>T178688 NZ_CP084209:c1119850-1118777 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9590.14 Da
• Isoelectric Point: 7.3180

>AT178688 WP_012551865.1 NZ_CP063683:c910312-910058 [Vibrio splendidus]
MKVELVTTLKRQATKILSELHASKEPVLITEHGQPSAYLLDVDDYEFMQKRIAILEGIARGEKAISDNRVVSHEVAKEKM
NKWL

Nucleotide

• Length: 255 bp

>AT178688 NZ_CP084209:c1118784-1118413 [Escherichia coli]
TTGTTTGAAATCACCGGAATTAACGTCTCAGGGGCTCTAAAAGCTGTCGTTATGGCGACCGGCTTCGAGAACCCTTTGTC
CTCAGTTAATGAAATTGAGACGAAACTTTCTGCCCTACTGGGTAGTGAGACCACTGGTGAAATCCTTTTTGACCTCTTGT
GCGCTAACGGTCCAGAGTGGAACCGCTTCGTTACGCTGGAAATGAAATATGGCCGGATCATGCTGGATACGGCCAAAATT
ATTGATGAGCAGGACGTTCCGACACATATCCTGAGCAAACTGACTTTTACTTTACGTAATCATCCTGAGTACCTAGAAGC
CTCTGTTTTGTCTCCCGATGATGTACGCCAAGTCCTGTCAATGGATTTTTGA

Structures

Toxin

• AlphaFold DB: Q5DZS7

Antitoxin

• AlphaFold DB: B6ERG3