Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3449546..3450184 Replicon chromosome
Accession NZ_CP063659
Organism Synechocystis sp. PCC 7339

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IQE94_RS16320 Protein ID WP_212719972.1
Coordinates 3449546..3449947 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IQE94_RS16325 Protein ID WP_212721948.1
Coordinates 3449957..3450184 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQE94_RS16295 (IQE94_16110) 3444866..3446140 - 1275 WP_223342307.1 glycosyltransferase family 4 protein -
IQE94_RS16300 (IQE94_16115) 3446204..3446746 - 543 WP_223343236.1 WcaF family extracellular polysaccharide biosynthesis acetyltransferase -
IQE94_RS16305 (IQE94_16120) 3446906..3447451 - 546 WP_223342308.1 Uma2 family endonuclease -
IQE94_RS16310 (IQE94_16125) 3447528..3448073 - 546 WP_223342309.1 DUF874 family protein -
IQE94_RS16315 (IQE94_16130) 3448247..3449434 - 1188 WP_223342310.1 glycosyltransferase -
IQE94_RS16320 (IQE94_16135) 3449546..3449947 - 402 WP_212719972.1 tRNA(fMet)-specific endonuclease VapC Toxin
IQE94_RS16325 (IQE94_16140) 3449957..3450184 - 228 WP_212721948.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IQE94_RS16330 (IQE94_16145) 3450252..3451442 - 1191 WP_212719971.1 glycosyltransferase family 4 protein -
IQE94_RS16335 (IQE94_16150) 3451462..3452832 - 1371 WP_223342311.1 hypothetical protein -
IQE94_RS16340 (IQE94_16155) 3452849..3454036 - 1188 WP_223342312.1 glycosyltransferase family 4 protein -
IQE94_RS16345 (IQE94_16160) 3454063..3454842 - 780 WP_223342313.1 FkbM family methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14972.48 Da        Isoelectric Point: 9.5071

>T178684 WP_212719972.1 NZ_CP063659:c3449947-3449546 [Synechocystis sp. PCC 7339]
MLKYMLDTNIVIYTMKNKPSQVRTLFKKHDGQMCISSVTLGELVFGAERSAMPEKNLSAIDNLIARMEVEFFDIKGATHF
GQIKAELAQRGTPIGPYDTMIAGHARSLGLILVTNNLKEFERIKGLRLENWAN

Download         Length: 402 bp

>T178684 NZ_CP084209:717224-717520 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8723.88 Da        Isoelectric Point: 6.9483

>AT178684 WP_212721948.1 NZ_CP063659:c3450184-3449957 [Synechocystis sp. PCC 7339]
IQTNVFRNNKTQAVRLPKMVELPENIKKITIVAVGNTRIITPVGESWDDWFDNCHVSSDFMNCREQPKDQSRESF

Download         Length: 228 bp

>AT178684 NZ_CP084209:717522-717917 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References