Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3935996..3936837 Replicon chromosome
Accession NZ_CP063518
Organism Escherichia coli strain EH01-18-02

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1M0WJM1
Locus tag IQS16_RS18865 Protein ID WP_000854822.1
Coordinates 3935996..3936379 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7MK11
Locus tag IQS16_RS18870 Protein ID WP_001285610.1
Coordinates 3936469..3936837 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS16_RS18835 3931642..3933483 + 1842 WP_000437371.1 RNA polymerase sigma factor RpoD -
IQS16_RS18840 3933561..3934067 - 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
IQS16_RS18850 3934366..3935211 - 846 WP_001280435.1 DUF4942 domain-containing protein -
IQS16_RS18855 3935308..3935505 - 198 WP_000839263.1 DUF957 domain-containing protein -
IQS16_RS18860 3935517..3936005 - 489 WP_001177592.1 hypothetical protein -
IQS16_RS18865 3935996..3936379 - 384 WP_000854822.1 type IV toxin-antitoxin system toxin CbtA Toxin
IQS16_RS18870 3936469..3936837 - 369 WP_001285610.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IQS16_RS18875 3936917..3937138 - 222 WP_000692350.1 DUF987 domain-containing protein -
IQS16_RS18880 3937207..3937683 - 477 WP_072661507.1 RadC family protein -
IQS16_RS18885 3937699..3938184 - 486 WP_072794436.1 antirestriction protein -
IQS16_RS18890 3938275..3939093 - 819 WP_001234702.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14295.32 Da        Isoelectric Point: 8.2830

>T178672 WP_000854822.1 NZ_CP063518:c3936379-3935996 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN

Download         Length: 384 bp

>T178672 NZ_CP084207:3417834-3417941 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13606.39 Da        Isoelectric Point: 6.0618

>AT178672 WP_001285610.1 NZ_CP063518:c3936837-3936469 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT178672 NZ_CP084207:c3417787-3417721 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0WJM1

Antitoxin

Source ID Structure

References