Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1853727..1854528 Replicon chromosome
Accession NZ_CP063518
Organism Escherichia coli strain EH01-18-02

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag IQS16_RS08710 Protein ID WP_000854739.1
Coordinates 1854148..1854528 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag IQS16_RS08705 Protein ID WP_001285482.1
Coordinates 1853727..1854101 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS16_RS08670 1849815..1850270 + 456 WP_000581502.1 hypothetical protein -
IQS16_RS08675 1850389..1850600 - 212 Protein_1678 hypothetical protein -
IQS16_RS08680 1850681..1851502 + 822 WP_001234710.1 DUF945 domain-containing protein -
IQS16_RS08685 1851765..1852238 + 474 WP_000855076.1 antirestriction protein -
IQS16_RS08690 1852254..1852730 + 477 WP_001186170.1 RadC family protein -
IQS16_RS08695 1852793..1853014 + 222 WP_000692315.1 DUF987 domain-containing protein -
IQS16_RS08700 1853033..1853677 + 645 WP_000086763.1 hypothetical protein -
IQS16_RS08705 1853727..1854101 + 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IQS16_RS08710 1854148..1854528 + 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
IQS16_RS08715 1854525..1855013 + 489 WP_001054232.1 hypothetical protein -
IQS16_RS08720 1855033..1855230 + 198 WP_000772027.1 DUF957 domain-containing protein -
IQS16_RS08725 1855315..1856142 + 828 WP_001304477.1 DUF4942 domain-containing protein -
IQS16_RS08735 1856629..1857567 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
IQS16_RS08740 1857622..1858359 + 738 WP_000283664.1 zinc-binding phosphatase -
IQS16_RS08745 1858383..1858937 + 555 WP_001001902.1 molecular chaperone YcdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T178655 WP_000854739.1 NZ_CP063518:1854148-1854528 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T178655 NZ_CP084207:c242955-242605 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT178655 WP_001285482.1 NZ_CP063518:1853727-1854101 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT178655 NZ_CP084207:c243200-242949 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGACGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References